Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Risk scores to predict mortality 2 and 5 years after surgery for colorectal cancer in elderly patients

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Basque Government (España); Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF); Instituto de Salud Carlos III; Kronikgune
    • بيانات النشر:
      BioMed Central (BMC)
    • الموضوع:
      2021
    • Collection:
      REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII)
    • نبذة مختصرة :
      Background: The aim of this study was to identify predictors of mortality in elderly patients undergoing colorectal cancer surgery and to develop a risk score. Methods: This was an observational prospective cohort study. Individuals over 80 years diagnosed with colorectal cancer and treated surgically were recruited in 18 hospitals in the Spanish National Health Service, between June 2010 and December 2012, and were followed up 1, 2, 3, and 5 years after surgery. Sociodemographic and clinical data were collected. The primary outcomes were mortality at 2 and between 2 and 5 years after the index admission. Results: The predictors of mortality 2 years after surgery were haemoglobin ≤ 10 g/dl and colon locations (HR 1.02; CI 0.51-2.02), ASA class of IV (HR 3.55; CI 1.91-6.58), residual tumour classification of R2 (HR 7.82; CI 3.11-19.62), TNM stage of III (HR 2.14; CI 1.23-3.72) or IV (HR 3.21; CI 1.47-7), LODDS of more than - 0.53 (HR 3.08; CI 1.62-5.86)) and complications during admission (HR 1.73; CI 1.07-2.80). Between 2 and 5 years of follow-up, the predictors were no tests performed within the first year of follow-up (HR 2.58; CI 1.21-5.46), any complication due to the treatment within the 2 years of follow-up (HR 2.47; CI 1.27-4.81), being between 85 and 89 and not having radiotherapy within the second year of follow-up (HR 1.60; CI 1.01-2.55), no colostomy closure within the 2 years of follow-up (HR 4.93; CI 1.48-16.41), medical complications (HR 1.61; CI 1.06-2.44), tumour recurrence within the 2 years of follow-up period (HR 3.19; CI 1.96-5.18), and readmissions at 1 or 2 years of follow-up after surgery (HR 1.44; CI 0.86-2.41). Conclusion: We have identified variables that, in our sample, predict mortality 2 and between 2 and 5 years after surgery for colorectal cancer older patients. We have also created risks scores, which could support the decision-making process. ; This work was supported in part by grants from the Spanish Health Research Fund (PS09/00314, PS09/00910, PS09/00746, PS09/00805, ...
    • ISSN:
      34446044
      1477-7819
    • Relation:
      Publisher's version; https://doi.org/10.1016/j.sleep.2016.04.019; info:eu-repo/grantAgreement/ES/PS09/00314; info:eu-repo/grantAgreement/ES/PS09/00910; info:eu-repo/grantAgreement/ES/PS09/00746; info:eu-repo/grantAgreement/ES/PS09/00805; info:eu-repo/grantAgreement/ES/PI09/90460; info:eu-repo/grantAgreement/ES/PI09/90490; info:eu-repo/grantAgreement/ES/PI09/90397; info:eu-repo/grantAgreement/ES/PI09/90453; info:eu-repo/grantAgreement/ES/PI09/90441; info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2013) (2013)/PI13/01692; info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2013) (2013)/PI13/00013; World J Surg Oncol. 2021;19(1):252.; http://hdl.handle.net/20.500.12105/14185; World Journal of Surgical Oncology
    • الرقم المعرف:
      10.1186/s12957-021-02356-6
    • Rights:
      http://creativecommons.org/licenses/by-nc-nd/4.0/ ; Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.33344C0E