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Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system

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  • معلومة اضافية
    • بيانات النشر:
      Hindawi Publishing Corporation
    • Collection:
      CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas)
    • نبذة مختصرة :
      The physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Angiotensin II, atrial natriuretic peptide and intrarenal dopamine play a pivotal role in this interactive network. The balance between endogenous antioxidant agents like the renal dopaminergic system and atrial natriuretic peptide, by one side, and the prooxidant effect of the renin angiotensin system, by the other side, contributes to ensuring the normal function of the kidney. Different pathological scenarios, as nephrotic syndrome and hypertension, where renal sodium excretion is altered, are associated with an impaired interaction between two natriuretic systems as the renal dopaminergic system and atrial natriuretic peptide that may be involved in the pathogenesis of renal diseases. The aim of this review is to update and comment the most recent evidences about the intracellular pathways involved in the relationship between endogenous antioxidant agents like the renal dopaminergic system and atrial natriuretic peptide and the prooxidant effect of the renin angiotensin system in the pathogenesis of renal inflammation. ; Fil: Rukavina Mikusic, Natalia Lucía. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Kravetz, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Kouyoumdzian, Nicolás Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Della Penna, S. L. ...
    • File Description:
      application/pdf
    • ISSN:
      2090-1739
    • Relation:
      info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jst/2014/731350/; http://hdl.handle.net/11336/98220; Rukavina Mikusic, Natalia Lucía; Kravetz, Maria Cecilia; Kouyoumdzian, Nicolás Martín; Della Penna, S. L.; Roson, Maria Ines; et al.; Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system; Hindawi Publishing Corporation; Journal of Signal Transduction; 2014; 11-2014; 1-15; 731350; CONICET Digital; CONICET
    • Rights:
      info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
    • الرقم المعرف:
      edsbas.32FA0E5E