Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Effects of milk thistle seed against aflatoxin B1 in broiler model

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • المؤلفون: Halimeh Amiridumari; Hadi Sarir; Omid FaniMakki; Nazar Afzali
  • المصدر:
    Journal of Research in Medical Sciences; Vol 18, No 9 (2013) ; مجله پژوهش در علوم پزشکی; Vol 18, No 9 (2013)
  • نوع التسجيلة:
    other/unknown material
  • اللغة:
    English
  • معلومة اضافية
    • بيانات النشر:
      Journal of Research in Medical Sciences
      مجله پژوهش در علوم پزشکی
    • الموضوع:
      2013
    • Collection:
      Isfahan University of Medical Sciences: MUI Periodicals
    • نبذة مختصرة :
      Background: Consumption of aflatoxin B1 (AFB1) contaminated products can pose a risk of development of various diseases in human and animals due to radical production. The scope of this work is to evaluate the efficacy of milk thistle seed (MTS), as a radical scavenger, on serum biochemistry, lipid profile and liver enzymes against AFB1 in broiler chickens contaminated with AFB1.Materials and Methods: The effect of nine experimental treatments (3 × 3 factorial design) was assessed using 216 one-d-old Ross 308 male broiler chicks in a randomized complete design with four replicates of six birds for each dietary treatments: Control (T1), 250 ppb AFB1 (T2), 500 ppb AFB1 (T3), 0.5% MTS (T4), 0.5% MTS Plus 250 ppb AFB1 (T5), 0.5% MTS Plus 500 ppb AFB1 (T6), 1.0% MTS (T7), 1.0% MTS Plus 250 ppb AFB1 (T8), and 1.0% MTS Plus 500 ppb AFB1 (T9). The individual and combined effects of dietary AFB1 and MTS on serum biochemistry factors (Glucose, Calcium, Phosphorus, Iron, Creatinine, and Uric acid), lipid profile (Triglyceride, Cholesterol, Low density lipoprotein (LDL), and High density lipoprotein (HDL)) and liver enzymes aspartate amino-transferase and alanine amino-transaminase (ALT) in broilers were evaluated at 21 days of age. Also, statistical packages Macros-1.002 (2010) were used to perform the above analysis on computer.Results: Consumption of 500 ppb AFB1 in to the diet significantly decreased HDL (58.13 ± 2.65), Calcium (7.11 ± 0.13), and Glucose (197.1 ± 7.42) compared to the control group (85.12 ± 1.95, 9.45 ± 0.17 and 223.1 ± 6.61, respectively), (P < 0.05). In contrast, it significantly increased creatinine (2.25 ± 0.011) and AST (244.51 ± 4.91). Using MTS together with AFB1 significantly reduced the effect of AFB1on the above parameters.Conclusion: MTS can provide protection against the negative effects of AFB1 on broiler chicks.Key words: Aflatoxin B1 (AFB1), fatty acid, liver enzymes, milk thistle seed (MTS), serum biochemistry
    • File Description:
      application/octetstream
    • Relation:
      http://journals.mui.ac.ir/jrms/article/view/9474
    • الدخول الالكتروني :
      http://journals.mui.ac.ir/jrms/article/view/9474
    • Rights:
      Journal of Research in Medical Sciences (JRMS) applies the Creative Commons Attribution License (CCAL) to all of its published papers. Under the CCAL, authors retain ownership of the copyright for their article, but authors allow anyone to download, reuse, reprint, modify, distribute, and/or copy articles in JRMS, so long as the original authors and source are cited. No permission is required from the authors or the publishers. [ License summary ] [ License full text ]
    • الرقم المعرف:
      edsbas.302DF0AE