Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Hypolipidemic and Hepatoprotective Effects of Polysaccharides Extracted from Liriope spicata Var. Prolifera in C57BL/6J Mice with High‐Fat Diet‐Induced Hyperlipidemia

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • Contributors:
      Youssef, Fadia S.; National Natural Science Foundation of China
    • بيانات النشر:
      Wiley
    • الموضوع:
      2020
    • Collection:
      Wiley Online Library (Open Access Articles via Crossref)
    • نبذة مختصرة :
      In this study, C57BL/6J mice with high‐fat diet‐ (HFD‐) induced hyperlipidemia were treated with total Liriope spicata var. prolifera polysaccharides (TLSP: 200, 400, and 800 mg/kg body weight), simvastatin (3 mg/kg body weight), or saline for 8 weeks, respectively. The results showed that TLSP had strong lipid‐lowering and hepatoprotective effects on C57BL/6J mice with HFD‐induced hyperlipidemia. TLSP administration significantly reduced serum total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein cholesterol (LDL‐C) levels and downregulated the expressions of peroxisome proliferator‐activated receptor (PPAR) γ and fatty acid synthase (FAS) in the adipose and liver tissues of the mice. TLSP exerted hypolipidemic and hepatoprotective effects by activating lipid/bile acid metabolism via the FXH‐SHP/CYP7A1 and SEBP‐1c/FAC/ACC signaling pathways. Thus, TLPS is a promising natural polymer with hepatoprotective and hypolipidemic properties.
    • الرقم المعرف:
      10.1155/2020/8013189
    • الدخول الالكتروني :
      http://dx.doi.org/10.1155/2020/8013189
      http://downloads.hindawi.com/journals/ecam/2020/8013189.pdf
      http://downloads.hindawi.com/journals/ecam/2020/8013189.xml
      https://onlinelibrary.wiley.com/doi/pdf/10.1155/2020/8013189
    • Rights:
      http://creativecommons.org/licenses/by/4.0/
    • الرقم المعرف:
      edsbas.2D8F0348