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Impact of early life nutrition on gut health in children: a prospective clinical study

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Université de Lille; CHU Lille; Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286; METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694; Institute for Translational Research in Inflammation - U 1286 INFINITE (Ex-Liric)
    • الموضوع:
      2024
    • Collection:
      LillOA (Lille Open Archive - Université de Lille)
    • نبذة مختصرة :
      Download PDFPDF XML Gastroenterology and hepatology Protocol Impact of early life nutrition on gut health in children: a prospective clinical study Delphine Ley1, Laurent Beghin1,2, Jules Morcel1,2, Florence Flamein2, Charles Garabedian3,4, Bertrand Accart5, Elodie Drumez4,6, Julien Labreuche4,6, Frederic Gottrand1,2, orcid:0000-0003-0971-4918Emmanuel Hermann1 Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France Univ. Lille, Inserm, CHU Lille, CIC-1403 Inserm-CHU, F-59000 Lille, France Univ. Lille, CHU Lille, Department of Obstetrics & Gynecology, F-59000 Lille, France Univ. Lille, CHU Lille, ULR 2694-METRICS: évaluation des technologies de santé et des pratiques médicales, F-59000 Lille, France CHU Lille - Inserm - UL, CRB/CIC1403, F-59037 Lille, France CHU Lille, Department of Biostatistics, F-59000 Lille, France Correspondence to Dr Emmanuel Hermann; emmanuel.hermann@univ-lille.fr Abstract Introduction The first 1000 days of life could contribute to individual susceptibility to the later development of chronic non-communicable diseases. Nutrition in early life appears to be an important determinant factor for a sustainable child’s health. In this study, we propose to investigate the impact of exclusive breast feeding on gut health in children. Methods and analysis A prospective cohort of newborns (n=350) will be recruited at birth and followed up to 4 years of age. The main objective is to evaluate the link between exclusive breast feeding for at least 3 months and the gut health of the child at 4 years. The primary endpoint of assessment of gut health will be based on the non-invasive measurement of faecal secretory IgA (sIgA) as a sensitive biomarker of the intestinal ecosystem. The presence of gastrointestinal disorders will be defined according to the clinical criteria of Rome IV. Information on parent’s nutritional habits and life style, breastfeeding duration and child’s complementary feeding will be collected along the ...
    • File Description:
      application/octet-stream
    • Relation:
      BMJ Open; http://hdl.handle.net/20.500.12210/90256
    • الدخول الالكتروني :
      https://hdl.handle.net/20.500.12210/90256
    • Rights:
      Attribution-NonCommercial 3.0 United States ; info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.2D64B4AF