Influência e interações (epistáticas e gene-ambiente) de SNPs na experiência de cárie: evidências a partir de revisões sistemáticas e estudos prospectivos ; Influence and interactions (epistatic and geneenvironment) of SNPs on caries experience: evidence from systematic reviews and prospective studies

It is unquestionable - and the literature strongly supports - that the main factors for the development and progression of caries disease are related to biological, behavioral and socioeconomic factors. However, some individuals exposed to the same risk and/or protective factors may have a different pattern of caries occurrence. Thus, recent studies have investigated the possibility of genetic influence on the occurrence of dental caries, aiming to explain this part of the effect not explained by known risk factors. Therefore, the aim of the present study was to investigate the influence and interaction (epistatic and geneenvironment) of Single Nucluotide Polimorphysm (SNPs) on dental caries experience from systematic reviews and prospective studies in the 1982 Pelotas birth cohort. Systematic reviews and meta-analyzes were conducted to identify genetic polymorphisms and their effects on dental caries experience in adults and children. The search strategy was performed using relevant keywords and between MeSH terms considering the structure of each database (PubMed / MedLine, Scopus, ISI Web of Science, VHL - Virtual Health Library, Scielo). Only human studies were included with cross-sectional and/or longitudinal design. No language restrictions or period of publication were considered. Studies with literature review design, case reports and case series, conference abstracts, letters to the editor, and qualitative studies were excluded. After identifying SNPs and their estimated effects on dental caries experience in reviews, prospective studies were conducted to evaluate the impact and reproduction of the effects of these SNPs on the birth cohort. Thus, a representative sample of all 5,914 live births from the 1982 Pelotas cohort were prospectively investigated and the prevalence of caries was assessed at 15 years (n = 888), 24 (n = 720) and 31 years (n = 539). Group-Based trajectory modeling was used to identify groups with similar trajectories of CPO-D “decayed” component. Genetic material was collected, and ...