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A case study on co-exposure to a mixture of organic solvents in a Tunisian adhesive-producing company

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  • معلومة اضافية
    • Contributors:
      École Nationale d'Ingénieurs de Sfax; Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur); Université de Sfax - University of Sfax; Faculté de Médecine Nancy; Université de Lorraine (UL); École des Hautes Études en Santé Publique EHESP (EHESP); Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL); This investigation was partly financially supported by Sfax University.
    • بيانات النشر:
      CCSD
      BioMed Central
    • الموضوع:
      2011
    • Collection:
      Inserm: HAL (Institut national de la santé et de la recherche médicale)
    • نبذة مختصرة :
      International audience ; UNLABELLED: ABSTRACT: OBJECTIVES: to assess environmental and biological monitoring of exposure to organic solvents in a glue-manufacturing company in Sfax, Tunisia. METHODS: Exposure of volunteer workers, in the solvented glue-work-stations, in the control laboratory and in the storage rooms of the finished products, was assessed through indoor-air and urine measurements. Informed consent of the workers was obtained. RESULTS AND DISCUSSION: The exposure indexes were found with high values in the solvented workshop as well as in the control laboratory and were respectively, 8.40 and 3.12. These indexes were also correlated with hexane and toluene indoor air concentrations. As to urine, the obtained results for the 2,5-hexandione and hippuric acid, metabolites of hexane and toluene, respectively, were in accord with the indoor-air measurements, with an average of 0.46 mg/l and 1240 mg/g of creatinine. CONCLUSION: This study assessed for the first time biological exposure to organic solvents used in Tunisian adhesive industries. Although values are likely to underestimate true exposure levels, some figures exceed European and American occupational exposure guidelines.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/22082240; PUBMED: 22082240; PUBMEDCENTRAL: PMC3226653
    • الرقم المعرف:
      10.1186/1745-6673-6-28
    • الدخول الالكتروني :
      https://inserm.hal.science/inserm-00646411
      https://inserm.hal.science/inserm-00646411v1/document
      https://inserm.hal.science/inserm-00646411v1/file/1745-6673-6-28.pdf
      https://doi.org/10.1186/1745-6673-6-28
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.2C66ACB3