Digital health technology for use in patients with serious mental illness: a systematic review of the literature

Sonal Batra,1 Ross A Baker,2 Tao Wang,3 Felicia Forma,4 Faith DiBiasi,3 Timothy Peters-Strickland5 1Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, 2Global Medical Affairs, Otsuka Pharmaceutical Development and Commercialization Inc., Princeton, NJ, 3Medical Affairs, Otsuka Pharmaceutical Development and Commercialization Inc., Rockville, MD, 4Health Economics and Outcomes Management, 5Global Clinical Development, Otsuka Pharmaceutical Development and Commercialization Inc., Princeton, NJ, USA Background: As the capabilities and reach of technology have expanded, there is an accompanying proliferation of digital technologies developed for use in the care of patients with mental illness. The objective of this review was to systematically search published literature to identify currently available health technologies and their intended uses for patients with serious mental illness.Materials and methods: The Medline, Embase, and BIOSIS Previews electronic databases were searched to identify peer-reviewed English language articles that reported the use of digital, mobile, and other advanced technology in patients with schizophrenia/schizoaffective disorder, bipolar disorder, and major depressive disorder. Eligible studies were systematically reviewed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Results: Eighteen studies that met the inclusion criteria were identified. Digital health technologies (DHTs) assessed in the selected studies included mobile applications (apps), digital medicine, digital personal health records, and an electronic pill container. Smartphone apps accounted for the largest share of DHTs. The intended uses of DHTs could be broadly classified as monitoring to gain a better understanding of illness, clinical assessment, and intervention. Overall, studies indicated high usability/feasibility and efficacy/effectiveness, with several reporting validity against established clinical scales. Users were generally ...