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Lipids and Transaminase in Antiretroviral-Treatment-Experienced People Living with HIV, Switching to a Doravirine-Based vs. a Rilpivirine-Based Regimen: Data from a Real-Life Setting

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  • معلومة اضافية
    • Contributors:
      Maggi, P; Ricci, E; Martinelli, C; De Socio, G; Squillace, N; Molteni, C; Masiello, A; Orofino, G; Menzaghi, B; Bellagamba, R; Vichi, F; Celesia, B; Madeddu, G; Pellicanò, G; Carleo, M; Cascio, A; Parisini, A; Taramasso, L; Valsecchi, L; Calza, L; Rusconi, S; Sarchi, E; Martini, S; Bargiacchi, O; Falasca, K; Cenderello, G; Ferrara, S; Di Biagio, A; Bonfanti, P
    • بيانات النشر:
      MDPI
      CH
    • الموضوع:
      2023
    • Collection:
      Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive)
    • نبذة مختصرة :
      Doravirine (DOR) is a newly approved non-nucleoside reverse transcriptase inhibitor (NNRTI). We aimed to investigate, in a real-life setting, how switching to a DOR-based regimen rather than a rilpivirine (RPV)-based regimen impacted metabolic and hepatic safety. The analysis included 551 antiretroviral treatment (ART)-experienced people living with HIV (PLWH), starting RPV-based or DOR-based regimens with viral load < 200 copies/mL, baseline (T0), and at least one control visit (6-month visit, T1). We enrolled 295 PLWH in the RPV and 256 in the DOR cohort. At T1, total cholesterol (TC), low-density lipoprotein-C (LDL-C), and triglycerides significantly decreased in both DOR and RPV cohorts, while high-density lipoprotein-C (HDL-C) only decreased in RPV-treated people. Consistently, the TC/HDL-C ratio declined more markedly in the DOR (−0.36, p < 0.0001) than in the RPV cohort (−0.08, p = 0.25) (comparison p = 0.39). Similar trends were observed when excluding the PLWH on lipid-lowering treatment from the analysis. People with normal alanine aminotransferase (ALT) levels showed a slight ALT increase in both cohorts, and those with baseline ALT > 40 IU/L experienced a significant decline (−14 IU/L, p = 0.008) only in the DOR cohort. Lipid profile improved in both cohorts, and there was a significant reduction in ALT in PLWH with higher-than-normal baseline levels on DOR-based ART.
    • File Description:
      ELETTRONICO
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/37515298; info:eu-repo/semantics/altIdentifier/wos/WOS:001041585700001; volume:15; issue:7; firstpage:1; lastpage:12; numberofpages:12; journal:VIRUSES; https://hdl.handle.net/10281/432218; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85165945782
    • الرقم المعرف:
      10.3390/v15071612
    • الدخول الالكتروني :
      https://hdl.handle.net/10281/432218
      https://doi.org/10.3390/v15071612
    • Rights:
      info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.2AA60FAF