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MYOCARDIUM PROTECTIVE FUNCTION OF SALVIANOLIC ACID B IN ISCHEMIA REPERFUSION RATS

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  • المؤلفون: Qiao, Zengyong; Xu, Yawei
  • المصدر:
    African Journal of Traditional, Complementary and Alternative Medicines; Vol 13 No 4 (2016); 157-161 ; 2505-0044 ; 0189-6016
  • الموضوع:
  • نوع التسجيلة:
    article in journal/newspaper
  • اللغة:
    English
  • معلومة اضافية
    • بيانات النشر:
      African Traditional, Herbal Medicine Supporters Initiative (ATHMSI)
    • الموضوع:
      2016
    • Collection:
      ATHMSI Journals
    • نبذة مختصرة :
      Background: Salvia miltiorrhiza (SM) Bunge is one of the widely-used Chinese medicinal herbs. Salvianolic acid B (Sal B), a bioactive compound isolated from the Chinese herb Radix Salviae Miltiorrhizae, has been reported to exhibit anti-inflammatory and anti-oxidantive effects. Material and method: To study the cardioprotective effects of salvianolic acid B (Sal B) on acute myocardial ischemia reperfusion (MIR) injury rats, on the basis of this investigation, the possible mechanism of salvianolic acid B was elucidated. Male Sprague- Dawley rats (200–220 g) were randomly divided into five groups: sham-operated, MIR, MIR + Sal B (10 mg/kg/day, orally), MIR + Sal B (20 mg/kg/day, orally) and MIR + Sal B (30 mg/kg/day, orally). Before operation, the foregoing groups were pretreated with homologous drug once a day for 7 days, respectively. After twelve hours in MIR, the cardioprotective effects of SPJ were evaluated by infarct size, biochemical values, and the antioxidative and antiapoptotic relative gene expressions. Results: Sal B significantly improved heart function and decreased infarct size; remarkably decreased levels of serum TNF-α and IL-1β levels, increased contents of myocardium antioxidant enzymes activities; western blot results showed that Sal B ameliorate the increased Bax and caspase-3 protins expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax. Conclusion: In ischemic myocardium, oxidative stress caused the overgeneration and accumulation of reactive oxygen species (ROS), which was central of cardiac ischemic injury. Sal B exerted beneficially cardioprotective effects on myocardial ischemia injury rats, mainly scavenging oxidative stress-triggered overgeneration and accumulation of ROS, alleviating myocardial ischemia injury and cardiac cell death.
    • File Description:
      application/pdf
    • Relation:
      https://journals.athmsi.org/index.php/ajtcam/article/view/4086/pdf; https://journals.athmsi.org/index.php/ajtcam/article/view/4086
    • الرقم المعرف:
      10.21010/ajtcam.v13i4.20
    • Rights:
      Copyright (c) 2016 Zengyong Qiao, Yawei Xu ; http://creativecommons.org/licenses/by/4.0
    • الرقم المعرف:
      edsbas.29C2A618