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Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Université de Montpellier (UM); Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Groupe de Recherche et d’Étude du Processus Inflammatoire (TIMC-GREPI); Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ); VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ); Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ); Université Grenoble Alpes (UGA); Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon); Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
    • بيانات النشر:
      HAL CCSD
      Sage Publications
    • الموضوع:
      2021
    • Collection:
      Université de Montpellier: HAL
    • نبذة مختصرة :
      International audience ; Tumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) are two pro-inflammatory cytokines involved in the pathophysiology of spondyloarthritis (SpA). Therapies targeting TNF-α or IL-17 are used as a second line among SpA patients failing non-steroidal anti-inflammatory drugs. The choice of such treatment has to take into account the patient’s comorbidities. Neurologic diseases are common and their association with SpA deserves to be studied. Therefore, the role of TNF-α and IL-17 cytokines is worth investigating in these neuropsychiatric diseases. This review aimed to explore the role of TNF-α and IL-17 in the pathogenesis of uveitis, multiple sclerosis, neuromyelitis optica, Alzheimer’s disease, Parkinson’s disease and depression. This update is critical to guide the therapeutic management of these co-morbidities in SpA patients.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/34290832; hal-03652850; https://hal.science/hal-03652850; https://hal.science/hal-03652850/document; https://hal.science/hal-03652850/file/1759720x211025894.pdf; PUBMED: 34290832; PUBMEDCENTRAL: PMC8273400; WOS: 000688101100001
    • الرقم المعرف:
      10.1177/1759720X211025894
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.2965CAA