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Quality of evidence of the efficacy of therapeutic interventions on patient-important outcomes in Cochrane's systematic reviews’ abstracts: A survey

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  • معلومة اضافية
    • Contributors:
      Collège Universitaire de Médecine Générale Lyon (CUMG); Université de Lyon; Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS); Département de médecine générale Université de Poitiers = Department of General Practice University of Poitiers (DMG); Université de Poitiers - Faculté de Médecine et de Pharmacie; Université de Poitiers = University of Poitiers (UP)-Université de Poitiers = University of Poitiers (UP); Centre d'Investigation Clinique Rennes (CIC); Université de Rennes (UR)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou -Institut National de la Santé et de la Recherche Médicale (INSERM); Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou; Fondation santé des Etudiants de France; Fondation Santé des Etudiants de France; Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Université de Tours (UT); AutomédiCation aCcompagnement Pluriprofessionnel PatienT (ACCePPT); Université Clermont Auvergne (UCA); Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); Centre de recherches sur la cognition et l'apprentissage UMR 7295 (CeRCA Poitiers ); Université de Poitiers = University of Poitiers (UP)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)
    • بيانات النشر:
      HAL CCSD
      Mary Ann Liebert
    • الموضوع:
      2021
    • Collection:
      HAL Lyon 1 (University Claude Bernard Lyon 1)
    • نبذة مختصرة :
      International audience ; OBJECTIVE: The objective of this study was to evaluate the proportion of therapeutics that have proven their efficacy on patient-important outcomes with a high quality of evidence among Cochrane systematic reviews (SRs). METHODS: We surveyed a random sample of 400 SRs’ abstracts published between September 2012 and December 2015, which compared therapeutic interventions with at least a placebo or no intervention control. The primary endpoint was the proportion of SRs with a statistically significant efficacy on a patient-important outcome and with a high quality of evidence. RESULTS: Among the 400 abstracts surveyed, 32 (8%) found efficacy on a patient-important outcome with a high quality of evidence. Half of the 400 SRs (50.2%) evaluated a pharmacological intervention and 12% of these found efficacy of the intervention on a patient-important outcome with a reported high quality of evidence. CONCLUSION: Based on an analysis of 400 abstracts of SRs from the Cochrane Collaboration, we found that there is a low number of therapeutic interventions which have proven their efficacy on patient-important outcomes with a high quality of evidence.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/33077183; hal-02978547; https://uca.hal.science/hal-02978547; https://uca.hal.science/hal-02978547/document; https://uca.hal.science/hal-02978547/file/Mayni%C3%A9-Francois%20et%20al-2020-Quality%20of%20evidence%20of%20the%20efficacy%20of%20therapeutic%20interventions.pdf; PUBMED: 33077183
    • الرقم المعرف:
      10.1016/j.therap.2020.09.004
    • الدخول الالكتروني :
      https://uca.hal.science/hal-02978547
      https://uca.hal.science/hal-02978547/document
      https://uca.hal.science/hal-02978547/file/Mayni%C3%A9-Francois%20et%20al-2020-Quality%20of%20evidence%20of%20the%20efficacy%20of%20therapeutic%20interventions.pdf
      https://doi.org/10.1016/j.therap.2020.09.004
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.294A1973