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Effects of an Exercise and Nutritional Intervention on Circulating Biomarkers and Metabolomic Profiling During Adjuvant Treatment for Localized Breast Cancer: Results From the PASAPAS Feasibility Randomized Controlled Trial

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  • معلومة اضافية
    • Contributors:
      Département cancer environnement (Centre Léon Bérard - Lyon); Centre Léon Bérard Lyon; ISA NMR Methods for Metabolism - Methodes RMN en métabolomique (2014-2018); Institut des Sciences Analytiques (ISA); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS); Unité de Nutrition Humaine (UNH); Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA); Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ); Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB Université de Savoie Université de Chambéry ); Laboratoire éducations et promotion de la santé (LEPS); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Nord; Health System Analysis Laboratory (GATE); Université de Lyon; Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB); Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA); Université Clermont Auvergne (UCA); Unité Ad Hoc INSERM 000008 "Radiations : Défense, Santé, Environnement" Lyon (Inserm U1296); Centre Léon Bérard Lyon -Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)
    • بيانات النشر:
      HAL CCSD
      SAGE Publications
    • الموضوع:
      2021
    • Collection:
      Institut National de la Recherche Agronomique: ProdINRA
    • نبذة مختصرة :
      International audience ; Purpose: Exercise has been shown to improve physical and psychological conditions during cancer therapy, but mechanisms remain poorly understood. The purpose of the present study was to report the results of cancer-related biomarkers and metabolomics outcomes from the PASAPAS feasibility study. Methods: In the PASAPAS randomized controlled trial, 61 women beginning adjuvant chemotherapy for localized breast cancer were randomized in a 6-month program of weekly aerobic exercises associated with nutritional counseling versus usual care with nutritional counseling. In the present analysis of 58 women for whom blood samples were available, first, circulating levels of biomarkers (ie, insulin, insulin-like growth factor 1, estradiol, adiponectin, leptin, interleukin-6, and tumor necrosis factor α) were measured at baseline and 6-month follow-up. Changes in biomarkers were compared between exercisers (n = 40) and controls (n = 18) using mixed-effect models. Second, serum metabolites were studied using an untargeted 1 H nuclear magnetic resonance spectroscopy, and orthogonal partial least squares analyses were performed to discriminate exercisers and controls at baseline and at 6 months. Results: Over the 6-month intervention, no statistically significant differences were observed between exercisers and controls regarding changes in biomarkers and metabolomic profiles. Conclusion: The present analysis of the PASAPAS feasibility trial did not reveal any improvement in circulating biomarkers nor identified metabolic signatures in exercisers versus controls during adjuvant breast cancer treatment. Larger studies preferably in women with poor physical activity level to avoid ceiling effect, testing different doses and types of exercise on additional biological pathways, could allow to clarify the mechanisms mediating beneficial effects of physical exercise during cancer treatment. Trial registration: ClinicalTrials.gov Identifier: NCT01331772. Registered 8 April 2011, ...
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/33655799; hal-03445390; https://hal.science/hal-03445390; https://hal.science/hal-03445390/document; https://hal.science/hal-03445390/file/1534735420977666.pdf; PUBMED: 33655799; PUBMEDCENTRAL: PMC7934026; WOS: 000626044400001
    • الرقم المعرف:
      10.1177/1534735420977666
    • Rights:
      http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.28E1D562