Internship Reports and Monography entitled “Whole-sporozoite vaccines against malaria: Current approaches and future prospects based on genetically modified Plasmodium berghei sporozoites” ; Relatórios de estágio e Monografia Intitulada “Whole-sporozoite vaccines against malaria: Current approaches and future prospects based on genetically modified Plasmodium berghei sporozoites”

Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia ; This document contains the SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis of the curricular internships realized in Community Pharmacy, at Farmácia Monte Formoso, and in Hospital Pharmacy, at Pharmaceutical Services of the Instituto Português de Oncologia de Coimbra Francisco Gentil. This is followed by the monography entitled "Whole sporozoite malaria vaccines: Current approaches and future prospects based on genetically modified Plasmodium berghei sporozoites". Malaria is an infectious potentially-lethal disease caused by the Plasmodium parasite. Despite all the efforts, it hasn’t been possible so far to achieve the ideal immunization approach and the eradication of this disease seems far away. Several vaccines targeting the different stages of the malaria life cycle have been developed, and the pre-erythrocytic vaccines report the best results. Despite the approval of the RTS,S subunit vaccine and its potential implementation in endemic areas, the results in terms of efficacy and long-lasting protection is not as good as desired. Whole-sporozoite vaccines are able to solve some obstacles of subunit vaccines. This document aims to describe the current whole-sporozoite vaccines approaches and a new strategy based on the rodent parasite Plasmodium berghei genetically modified. This recent approach has shown very promising results in inserting selected antigens to establish immunity against the parasites that currently most infect humans and can cause severe disease (Plasmodium falciparum and Plasmodium vivax). ; O presente documento integra a análise SWOT (Strengths, Weaknesses, Opportunities and Threats) aos estágios curriculares realizados em Farmácia Cumunitária, na Farmácia Monte Formoso, e ao estágio em Farmácia Hospitalar, nos Serviços Farmacêuticos do Instituto Português de Oncologia de Coimbra Francisco Gentil. De seguida, é exposta a monografia intitulada “Whole-sporozoite ...