Organochlorine exposure and changes in the perinatal period: a review ; Exposición a organoclorados y cambios en el período perinatal: una revisión ; Exposição a organoclorados e alterações no período perinatal: uma revisão

Objective: The aim of this review is to survey the state of the art on key perinatal outcomes associated with contamination by organochlorines. Data Source: This is an integrative review. A search was performed in MEDLINE / PubMed for the descriptors “organochlorine” AND “infertility”; “organochlorine” AND “fetal loss”; “organochlorine” AND “preterm delivery”; and “organochlorine” AND “low birth weight,” without time restrictions. As an exclusion criterion, we only considered the analytical studies of bench and animal studies. Data Synthesis: There is great scientific interest in one group of chemicals present in the environment that interfere with the endocrine system’s chemicals and thereby affect health, growth and reproduction, including organochlorine pesticides, which are substances that are extremely persistent in the environment. By mimicking estrogen and androgenic steroids, perinatal outcomes are particularly interesting for evaluating the consequences of chronic exposure to organochlorines. The state of art about how these substances interfere with the human body, especially the endocrine-reproductive axis, is not yet consolidated. Conclusions: It was observed that there is no consensus on the relation between an exposure to organochlorines and perinatal outcomes, although there are indications that there is a cause and effect relationship between the variables. ; Objetivo: El objetivo de esta revisión es evaluar el estado de situación de los estudios relacionados con los resultados perinatales asociados a la contaminación por organoclorados. Fuente de datos: Se trata de una revisión sistemática que se realizó con estudios identificados en la búsqueda en MEDLINE / PubMed, por los descriptores “Organoclhorine” e “infertilidad”; “Organoclorados” y la “pérdida fetal”; “Organoclorados y parto prematuro”; y “organoclorados” y “bajo peso al nacer”, sin corte temporal. Como criterio de exclusión, se consideraron los estudios analíticos realizados en el laboratorio y los estudios con animales. ...