Сравнительная характеристика состояния печени у пациентов с абдоминальным ожирением и с хроническим вирусным гепатитом ; Liver status in patients with abdominal obesity vs chronic viral hepatitis: a comparative study

Background: Liver fibrosis (LF) is a great medical and social problem, in this regard identifying the early stages of fibrosis are very important for clinical practice. Transient elastography is a modern non-invasive method to assess liver stiffness in adults. This investigation was devoted to prevalence of any stages liver fibrosis (LF), identifying general risk factors in early stage and to propose screening strategies in therapeutic practice. Aim: The purpose of this report is to determine frequency of liver fibrosis among obese patients in comparison with healthy people and patients with viral hepatitis. Methods: Were examined 258 adults: the following data were recorded some blood tests included ASAT/ALAT, GGT, bilirubin, glucose, cholesterol and triglycerides, markers of viral hepatitis (HV). All patients underwent ultrasound research and elastography. Results: Normal subjects had significantly lower liver stiffness (LS) than patients in other groups, medians 4,39+0,99 (25% - 75%: 4,18-4,60) kPa, p<0,0011. In this group 7 subjects (8,05%) had mild liver fibrosis. Obese persons had different parameters of LS -medians 7,03 (25% - 75%: 6,39 - 7,67) kPa; in this group 48 people had fibrosis 1-4 stages (30,86%, 17,28% and 11,11% respectively). This results were correlated with LSM in the third group (persons with HCV orNand HBV) -medians 8,00 (25% - 75%: 6,2 - 9,8) kPa. The characteristics of liver stiffness were associated with gender, BMI, alcohol intake and presence of obesity.Conclusions: In our study liver fibrosis has been linked to obesity, viral hepatitis. The other risk factors were alcohol consumption and arterial hypertension. Obese persons haven't difference LSM in comparison with patients with chronic viral hepatitis. People might be examined by transient elastography for LF detection. Transcient elastography is a useful non-invasive method for LSM. New researches should be performed in different groups of patients with obesity for assessment prognostic significance of transcient elastography in ...