Contributors: Centre Hospitalier Universitaire d'Angers (CHU Angers); PRES Université Nantes Angers Le Mans (UNAM); Laboratoire de Psychologie des Pays de la Loire (LPPL); Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL); Université de Nantes (UN)-Université de Nantes (UN); CHU Rouen; Normandie Université (NU); School of Arts and Sciences Lebanese American University (SAS/LAU); Lebanese American University (LAU); Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Université Paris Diderot - Paris 7 (UPD7); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Institut Mutualiste de Montsouris (IMM); Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab); Université de Lille-Centre National de la Recherche Scientifique (CNRS); Hôpital Saint-Vincent de Paul; Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ); Agence Nationale de la Recherche, ANR Institut National de la Santé et de la Recherche Médicale, Inserm Fondation de France Ministère des Affaires Sociales et de la Santé; EVHAN study was supported by grants from the French Ministry of Health (PHRCN 2007, 2011 AOM11197; ANR Jeune chercheur, Bourse de thèse Eiffel) and from CNAM-TS, Fondation de France, Fondation MGEN, EHESP, AP-HP, CIFRE, and Contrats d’interface INSERM.
نبذة مختصرة : International audience ; Purpose: The relationship between anxiety or depressive comorbidities, their chronology of onset, and the severity of anorexia nervosa (AN) is not well-studied. We hypothesize that the existence of a comorbidity, particularly before the onset of AN, is associated with greater severity of AN. Methods: One hundred seventy-seven subjects were assessed. The prevalence of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD), and social phobia (SP) as well as their chronology of onset were studied. The assessment criteria of AN severity were the overall clinical condition, body mass index (BMI) on admission, lowest BMI, intensity of the eating symptoms, age at the onset of AN, illness duration, number of hospitalizations, and quality of life. Results: Patients with AN had the greatest clinical severity when they had a comorbid disorder over their lifetime, such as MDD, GAD, or SP. These comorbidities along with OCD were associated with a higher level of eating symptoms and a more altered quality of life. A profile of maximum severity was associated with a higher prevalence of MDD and GAD. Concerning the chronology of onset, the age at the start of AN was later in cases of MDD or GAD prior to AN. Conclusion: There seems to be an association between severity of AN and both MDD and GAD. The chronology of onset of the comorbidity did not seem to be associated with the severity.
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