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Future options of anti-angiogenic cancer therapy

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Linköpings universitet, Medicinska fakulteten
      Linköpings universitet, Avdelningen för kardiovaskulär medicin
      Karolinska Institute, Sweden; University of Leicester, England; Glenfield Hospital, England
      SUN YAT SEN UNIV MED SCI WHO
    • الموضوع:
      2016
    • Collection:
      Linköping University Electronic Press (LiU E-Press)
    • نبذة مختصرة :
      In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival benefits; however, the addition of an anti-angiogenic component to conventional therapeutic modalities has generally produced modest survival benefits for cancer patients. Currently, it is unclear why these clinically available drugs targeting the same angiogenic pathways produce dissimilar effects in preclinical models and human patients. In this article, we discuss possible mechanisms of various anti-angiogenic drugs and the future development of optimized treatment regimens. ; Funding Agencies|European Research Council advanced grant ANGIOFAT [250021]; Swedish Research Council; Swedish Cancer Foundation; Karolinska Institute Foundation; Karolinska Institute Distinguished Professor Award; Torsten Soderberg Foundation; Novo Nordisk Foundation; Knut and Alice Wallenberg Foundation
    • File Description:
      application/pdf
    • Relation:
      CHINESE JOURNAL OF CANCER, 1000-467X, 2016, 35:21; http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-125802; PMID 26879126; ISI:000370009400002
    • الرقم المعرف:
      10.1186/s40880-016-0084-4
    • الدخول الالكتروني :
      http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-125802
      https://doi.org/10.1186/s40880-016-0084-4
    • Rights:
      info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.2318575B