Comparative Evaluation of effect of Telmisartan and Olmesartan on Blood Pressure and Fasting Blood Glucose Levels in Newly Diagnosed Hypertensive Patients: An Open Label Prospective Randomized Clinical Study

Title: Comparative evaluation of effect of Telmisartan and Olmesartan on blood pressure and fasting blood glucose levels in newly diagnosed hypertensive patients: An open label prospective randomized clinical study. Introduction: Hypertension is responsible for development of diseases like stroke, ischemic heart disease and end organ damage. Angiotensin receptor blockers like Telmisartan & Olmesartan are first line drug for the treatment of hypertension. These drugs having pleotropic, anti-oxidant and anti-inflammatory effect. Primary objective of the study was to evaluate mean change in systolic and diastolic blood pressure from day 0 to 12 th week. Secondary objectives were to determine the mean change in fasting blood sugar from day 0 to 12 th week and to evaluate the safety of the study drugs. Material and Method: It was a prospective, open label, interventional, comparative, randomized study. Total of 109 newly diagnosed patients of hypertension were enrolled and divided in two groups. Patients in group A received tablet Telmisartan 40 mg once in a day and patients in group B received tablet Olmesartan 20 mg once in day. Results: In Telmisartan group, the baseline mean SBP and DBP was 151.6 ± 3.113 mm Hg and 90.83 ± 2.50 mm Hg which reduced to 137.16 ± 2.135 mm Hg and 81.79 ± 1.94 mm Hg respectively at 12 th week and in Olmesartan group, the baseline mean SBP and DBP was 151.74 ± 4.54 mm Hg and 91.53 ± 3.28 mm Hg which reduced to 134.17 ± 3.43 mm Hg and 80.64 ± 2.76 mm Hg respectively at 12 th week. The reduction in mean SBP and DBP was statistically significant at the end of therapy in both groups. There was no significant reduction in fasting blood glucose level in both study groups. Conclusion: Both Telmisartan and Olmesartan effectively controlled systolic and diastolic blood pressure in hypertensive patients but reduction was more significant in Olmesartan group. Both these drugs having no significant effect on fasting blood glucose level. ; Title: Comparative evaluation of effect of Telmisartan ...