Contributors: Icahn School of Medicine at Mount Sinai New York (MSSM); Institut de recherche en santé, environnement et travail (Irset); Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; International Prevention Research Institute (IPRI); Universidade Federal de Pelotas = Federal University of Pelotas (UFPel); Universidade de São Paulo = University of São Paulo (USP); Leibniz Institute for Prevention Research and Epidemiology - BIPS; Leibniz Association; National and Kapodistrian University of Athens (NKUA); Università degli studi di Torino = University of Turin (UNITO); Cancer Registry of Norway; University of Glasgow; The University of Hong Kong (HKU); Penn State College of Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System; National Institute of Public Health Romania (INSP); Heidelberg University Hospital Heidelberg; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Universität Heidelberg Heidelberg = Heidelberg University; German Cancer Research Center - Deutsches Krebsforschungszentrum Heidelberg (DKFZ); School of Medicine University of Utah, Salt Lake City; University of Utah; Università degli Studi di Milano = University of Milan (UNIMI); International Agency for Cancer Research (IACR); The INHANCE Consortium was supported by NIH grants NCI R03CA113157 and NIDCR R03DE016611. Studies participating in the pooled analysis were supported by: Latin America study: Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina, IMIM (Barcelona), Fundaco de Amparo a` Pesquisa no Estado de Sao Paulo (FAPESP) No 01/01768–2 , and European Commission IC18-CT97–0222 . Sao Paulo: Sao Paulo Research Foundation (FAPESP) (GENCAPO 04/12054–9, 10/51168–0). Western Europe multicenter (ARCAGE): European Community (5th Framework Programme) grant no QLK1-CT-2001-00182. New York multicenter: NY multicenter study: NIH P01CA068384 K07CA104231 . Central Europe multicenter (INCO): Central Europe study: World Cancer Research Fund and the European Commission INCO-COPERNICUS Program Contract No. IC15- CT98–0332 . Tampa study: NIH P01CA068384, K07CA104231, R01DE013158 Germany-Heidelberg: Germany-Heidelberg study: grant No. 01GB9702/3 from the German Ministry of Education and Research. Seattle-Leo: Seattle-LEO study: NIH R01CA030022 . MSKCC: MSKCC study: NIH R01CA051845 . Germany-Saarland: Saarland study: Ministry of Science, Research and Arts Baden-Wurttemberg. France multicenter (ICARE): French National Research Agency (ANR); French National Cancer Institute (INCA); French Agency for Food, Environmental and Occupational Health and Safety (ANSES); French Association for Research on Cancer (ARC); Fondation pour la Recherche Médicale (FRM); French Institute for Public Health Surveillance (InVS); Fondation de France; Ministry of Labour; Ministry of Health
نبذة مختصرة : International audience ; Objective: To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods: We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC × (OR - 1)/OR.Results: Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR = 1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR = 1.38; 95% CI 1.13 to 1.69), painters (OR = 1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions: We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.
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