Contributors: 1 deCODE Genetics/Amgen, Inc., Reykjavik, 101, Iceland. 2 Department of Clinical Biochemistry, Landspítali University Hospital, Reykjavik, 101, Iceland. 3 Laboratory in Mjódd (RAM), Reykjavik, 109, Iceland. 4 Department of Clinical Biochemistry, Akureyri Hospital, Akureyri, 600, Iceland. 5 Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland. 6 Department of Immunology, Landspitali University Hospital, Reykjavik, 101, Iceland. 7 Department of Internal Medicine, Landspitali University Hospital, Reykjavik, 101, Iceland. 8 Department of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, 101, Iceland. 9 School of Engineering and Natural Sciences, University of Iceland, Reykjavik, 101, Iceland. 10 deCODE Genetics/Amgen, Inc., Reykjavik, 101, Iceland. patrick.sulem@decode.is. 11 deCODE Genetics/Amgen, Inc., Reykjavik, 101, Iceland. kstefans@decode.is. 12 Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland. kstefans@decode.is.
نبذة مختصرة : To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download ; Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genome-wide association studies of gallstone disease in Iceland and the UK, totaling 27,174 cases and 736,838 controls, uncovering 21 novel gallstone-associated variants at 20 loci. Two distinct low frequency missense variants in SLC10A2, encoding the apical sodium-dependent bile acid transporter (ASBT), associate with an increased risk of gallstone disease (Pro290Ser: OR = 1.36 [1.25-1.49], P = 2.1 × 10
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