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Comment on \'ilc1 drive intestinal epithelial and matrix remodeling\'

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  • معلومة اضافية
    • Contributors:
      Institute for Translational Research in Inflammation - U 1286 (INFINITE); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Lille Inflammation Research International Center - U 995 (LIRIC); Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)
    • بيانات النشر:
      CCSD
      Nature Pub. Group
    • الموضوع:
      2021
    • Collection:
      LillOA (HAL Lille Open Archive, Université de Lille)
    • نبذة مختصرة :
      International audience ; Type 1 Innate lymphoid cells (ILC1) accumulate in the inflamed mucosa of patients with Crohn’s disease (CD) but their role in CD pathogenesis remains poorly known. In a recent issue of Nature materials, Jowett et al. (Nat. Mat. 2020) used a coculture model with intestinal organoids to show that ILC1 could promote intestinal epithelial growth and tissue remodeling through an unexpected mechanism that involves the transforming growth factor 1 (TGF-β1) and the metalloproteinase MMP9.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/33542491; PUBMED: 33542491
    • الرقم المعرف:
      10.1038/s41385-020-00360-9
    • الدخول الالكتروني :
      https://hal.univ-lille.fr/hal-04490130
      https://hal.univ-lille.fr/hal-04490130v1/document
      https://hal.univ-lille.fr/hal-04490130v1/file/PIIS1933021922001295.pdf
      https://doi.org/10.1038/s41385-020-00360-9
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.1CD57FC3