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Comparative analysis of chemical composition, antimicrobial, antioxidant and spasmolytic activity of essential oils of Cymbopogon nervatus (Hochst.) Chiov. and Cymbopogon schoenanthus (L.) Spreng (Poaceae) from Sudan ; Uporedna analiza hemijskog sastava, antimikrobne, antioksidantne i spazmolitičke aktivnosti etarskog ulja Cymbopogon nervatus (Hochst.) Chiov. i Cymbopogon schoenanthus (L.) Spreng (Poaceae) iz Sudana

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Kovačević, Nada; Drobac, Milica; Branković, Suzana
    • بيانات النشر:
      Универзитет у Београду, Фармацеутски факултет
    • الموضوع:
      2020
    • Collection:
      NaRDuS (National Repository of Dissertations in Serbia) / Nacionalni Repozitorijum Disertacija u Srbiji
    • نبذة مختصرة :
      This PhD dissertation deals with investigation of two species from genus Cymbopogon, Cymbopogon nervatus (Hochst.) Chiov. and Cymbopogon schoenanthus (L.) Spreng. collected in Sudan. They were investigated in terms of content and detailed chemical analysis of essential oils obtained from different plant parts and collected in different time periods. In addition, essential oils from both species were investigated for antimicrobial, antioxidant and spasmolytic activities. For analyses of essential oils, obtained by steam distillation from dried plant material, GC and GC-MS were applied. The most dominant constituents in the oils of C. nervatus were p-menthadienols: trans-p-mentha-1(7),8-dien-2-ol (19.9-32.6%), cisp- mentha-1(7),8-dien-2-ol (18.9-23.3%), trans-p-mentha-2,8-dien-1-ol (10.6-21.0%) and cis-p-mentha-2,8-dien-1-ol (8.1-10.4%). The major constituents in the oils of C. schoenanthus were piperitone (47.7-71.5%), intermedeol (6.1-17.3%), δ-2-carene (4.5-10.0%) and elemol (2.7-9.0%). The antimicrobial activities of the essential oils of both plants were tested using broth microdilution method against seven standard strains of bacteria and two strains of fungi. MIC values obtained for the essential oils of C. nervatus were in the range of 783-1060 μg/ml and those for C. schoenanthus were 771-1300 μg/ml. It was concluded that investigated essential oils exhibited weak antimicrobial activity. The total antioxidant capacity of the investigated essential oils estimated by Ferric Reducing Antioxidant Power (FRAP) test was in the range of 2.03-2.88 nmol Fe/mg EO for C. nervatus essential oils and for C. schoenanthus in the range of 2.49- 2.96 nmol Fe/mg and weaker than the capacity of rutin (5.17 μmol Fe/mg) and ascorbic acid (10.40 μmol Fe/mg) used as the referent antioxidants. In the DPPH radical scavenging assay, essential oil of C. nervatus showed moderate activity with SC50 value of 23.8 μl/ml. DPPH scavenging activity of essential oils of C. schoenanthus represented by percentage (%) of inhibition was ...
    • File Description:
      application/pdf
    • Relation:
      https://nardus.mpn.gov.rs/handle/123456789/8113; http://eteze.bg.ac.rs/application/showtheses?thesesId=4972; https://fedorabg.bg.ac.rs/fedora/get/o:15610/bdef:Content/download; http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48964111; http://nardus.mpn.gov.rs/bitstream/id/24425/Disertacija.pdf; http://nardus.mpn.gov.rs/bitstream/id/24426/IzvestajKomisije9335.pdf; https://nardus.mpn.gov.rs/bitstream/id/24426/IzvestajKomisije9335.pdf; https://nardus.mpn.gov.rs/bitstream/id/24425/Disertacija.pdf; https://hdl.handle.net/21.15107/rcub_nardus_8113
    • Rights:
      openAccess ; https://creativecommons.org/licenses/by-nc/4.0/ ; BY-NC
    • الرقم المعرف:
      edsbas.1B812F6C