Contributors: Matière et Systèmes Complexes (MSC); Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Laboratoire des Sciences des Procédés et des Matériaux (LSPM); Institut Galilée-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris); Université Paris Sciences et Lettres (PSL); Laboratoire Rhéologie et Procédés (LRP); Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ); Université Grenoble Alpes (UGA); Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); ANR-10-LABX-0096,SEAM,Science and Engineering for Advanced Materials and devices(2010); ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018); ANR-16-CARN-0025,PolyNat Carnot Institute,PolyNat Carnot Institute(2011); ANR-11-LABX-0030,TEC XXI,Ingénierie de la Complexité : la mécanique et ses interfaces au service des enjeux sociétaux du 21iè(2011)
نبذة مختصرة : International audience ; In order to get better knowledge of mechanical properties from microscopic to macroscopic scale of biopolymers, viscoelastic bulk properties of aqueous solutions of sodium alginate were studied at different scales by combining macroscopic shear rheology (Hz), diffusing-wave spectroscopy microrheology (kHz-MHz) and Brillouin spectroscopy (GHz). Structural properties were also directly probed by small-angle X-ray scattering (SAXS). The results demonstrate a change from polyelectrolyte behavior to neutral polymer behavior by increasing polymer concentration with the determination of characteristic sizes (persistence length, correlation length). The viscoelastic properties probed at the phonon wavelength much higher than the ones obtained at low frequency reflect the variation of microscopic viscosity. First experiments obtained by metabolic activity assays with mouse embryonic fibroblasts showed biocompatibility of sodium alginate aqueous solutions in the studied range of concentrations (2.5-10 g L À1) and consequently their potential biomedical applications.
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