نبذة مختصرة : The aim of the study – to evaluate IL-6 and TNF-a levels in children with COVID-19 and their dependence on the severity of the disease Materials and Methods. 112 children with COVID-19, aged 1 month to 18 years, who were hospitalized at the Department of Infectious Diseases of Ternopil City Children's Hospital were examined. The level of IL-6 and TNF-a in serum samples was determined by enzyme-linked immunosorbent assay using standard kits (BT Lab, China). Results and Discussion. The average age of children was (7.04±5.75) years (95% CI 5.96−8.12). Regarding disease severity, 57 children (42.23%) had a mild course of the disease, 43 children (31.86%) had a moderate course, and 12 children (8.88%) had a severe course. The concentration of IL-6 in children with a mild course of COVID-19 was 80.36 ng/ml; with a moderate course – 101ng/ml; with a severe course – 151.90 ng/ml (р<0.001). The level of TNF-a in mild COVID-19 was 56.7 ng/ml; 97.73 ng/ml – in moderate disease severity, and 182.42 ng/ml – in severe cases (р<0.001). Conclusions. The level of cytokines IL-6 and TNF-a in children with COVID-19 depends on the severity of the disease. Patients with severe COVID-19 have significantly higher levels of IL-6 and TNF-α compared to mild and moderate COVID-19. Correlative relationships between high levels of IL-6, TNF-α and C-reactive protein, ESR, and lymphocytes were found in children with COVID-19. No gender patterns were found in relation to cytokines (IL-6, TNF-α) and age-specific characteristics in relation to TNF-α indicators. ; Мета дослідження – оцінити показники IL-6 та TNF-α у дітей із COVID-19 та їх залежність від ступеня тяжкості захворювання. Матеріали та методи. Обстежено 112 дітей із COVID-19 віком від 1 місяця до 18 років, які перебували на стаціонарному лікуванні в інфекційному відділенні Тернопільської міської дитячої лікарні. Рівень IL-6 і TNF-α у зразках сироватки крові визначали методом імуноферментного аналізу з використанням стандартних наборів (BT Lab, Китай). Результати дослідження та ...
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