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A GATE/Geant4 beam model for the MedAustron non-isocentric proton treatment plans quality assurance

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  • معلومة اضافية
    • Contributors:
      EBG MedAustron GmbH; Medizinische Universität Wien = Medical University of Vienna; National Physical Laboratory Teddington (NPL); Imagerie Tomographique et Radiothérapie; Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon); Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); ANR-11-IDEX-0007,Avenir L.S.E.,PROJET AVENIR LYON SAINT-ETIENNE(2011); ANR-11-LABX-0063,PRIMES,Physique, Radiobiologie, Imagerie Médicale et Simulation(2011)
    • بيانات النشر:
      HAL CCSD
      Elsevier
    • الموضوع:
      2020
    • Collection:
      Université Jean Monnet – Saint-Etienne: HAL
    • نبذة مختصرة :
      International audience ; Highlights •The treatment head design implemented in the MC beam model allows the characterization of the secondary spectra radiation. •The beam model is calibrated in absolute dose based on a recent formalism in terms of a Dose-Area-Product within 1.2% •The beam model is validated within clinical constraints including non-isocentric conditions. •33 non-isocentric clinical fields are reproduced within 1% when the average dose gradient is less than 1%/mm. •The model serves as reference for future clinical as well as research work.AbstractPurposeTo present a reference Monte Carlo (MC) beam model developed in GATE/Geant4 for the MedAustron fixed beam line. The proposed model includes an absolute dose calibration in Dose-Area-Product (DAP) and it has been validated within clinical tolerances for non-isocentric treatments as routinely performed at MedAustron.Material and MethodsThe proton beam model was parametrized at the nozzle entrance considering optic and energy properties of the pencil beam. The calibration in terms of absorbed dose to water was performed exploiting the relationship between number of particles and DAP by mean of a recent formalism. Typical longitudinal dose distribution parameters (range, distal penumbra and modulation) and transverse dose distribution parameters (spot sizes, field sizes and lateral penumbra) were evaluated. The model was validated in water, considering regular-shaped dose distribution as well as clinical plans delivered in non-isocentric conditions.ResultsSimulated parameters agree with measurements within the clinical requirements at different air gaps. The agreement of distal and longitudinal dose distribution parameters is mostly better than 1 mm. The dose difference in reference conditions and for 3D dose delivery in water is within 0.5% and 1.2%, respectively. Clinical plans were reproduced within 3%.ConclusionA full nozzle beam model for active scanning proton pencil beam is described using GATE/Geant4. Absolute dose calibration based on DAP ...
    • Relation:
      hal-02505728; https://hal.science/hal-02505728; https://hal.science/hal-02505728/document; https://hal.science/hal-02505728/file/hal-02505728.pdf
    • الرقم المعرف:
      10.1016/j.ejmp.2020.02.006
    • الدخول الالكتروني :
      https://doi.org/10.1016/j.ejmp.2020.02.006
      https://hal.science/hal-02505728
      https://hal.science/hal-02505728/document
      https://hal.science/hal-02505728/file/hal-02505728.pdf
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.18680609