Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Synergistic interactions of indole-2-carboxamides and β-lactam antibiotics against Mycobacterium abscessus

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Institut de Recherche en Infectiologie de Montpellier (IRIM); Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS); Marshall B. Ketchum University Fullerton, CA, USA (MBKU); Roosevelt University Chicago; Colorado State University Fort Collins (CSU); Starwise Therapeutics LLC Chicago; Institut National de la Santé et de la Recherche Médicale (INSERM); This study was supported by the Association Gregory Lemarchal and Vaincre la Mucoviscidose (RIF20180502320) to LK. MDJ received a post-doctoral fellowship granted by Labex EpiGenMed, an «Investissements d’avenir» program (ANR-10-LABX-12-01).; ANR-10-LABX-0012,EpiGenMed,From Genome and Epigenome to Molecular Medicine: turning new paradigms in biology into the therapeutic strategies of tomorrow(2010)
    • بيانات النشر:
      HAL CCSD
      American Society for Microbiology
    • الموضوع:
      2020
    • Collection:
      Université de Montpellier: HAL
    • نبذة مختصرة :
      International audience ; New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus. We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/32041716; hal-02479144; https://hal.science/hal-02479144; https://hal.science/hal-02479144/document; https://hal.science/hal-02479144/file/AAC02548-19R1_Merged_PDF%282%29.pdf; PUBMED: 32041716
    • الرقم المعرف:
      10.1128/AAC.02548-19
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.183503B6