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A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

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  • معلومة اضافية
    • Contributors:
      Institut Pasteur Paris (IP); Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Laboratoire des biomolécules (LBM UMR 7203); Chimie Moléculaire de Paris Centre (FR 2769); École normale supérieure - Paris (ENS-PSL); Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP); Université Paris Sciences et Lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris); Université Paris Sciences et Lettres (PSL)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL); Université Paris Sciences et Lettres (PSL)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département de Chimie - ENS Paris; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); This work was supported in part by the Centre National de la Recherche Scientifique (CNRS), the Institut National de la Santé Et de la Recherche Médicale (INSERM) and the Institut Pasteur.
    • بيانات النشر:
      HAL CCSD
      Frontiers
    • الموضوع:
      2024
    • Collection:
      ESPCI ParisTech: HAL (Ecole Supérieure de Physique et Chimie Industrielles)
    • نبذة مختصرة :
      International audience ; De novo purine nucleotide biosynthesis (DNPNB) consists of sequential reactions that are majorly conserved in living organisms. Several regulation events take place to maintain physiological concentrations of adenylate and guanylate nucleotides in cells and to fine-tune the production of purine nucleotides in response to changing cellular demands. Recent years have seen a renewed interest in the DNPNB enzymes, with some being highlighted as promising targets for therapeutic molecules. Herein, a review of two newly revealed modes of regulation of the DNPNB pathway has been carried out: i) the unprecedent allosteric regulation of one of the limiting enzymes of the pathway named inosine 5′-monophosphate dehydrogenase (IMPDH), and ii) the supramolecular assembly of DNPNB enzymes. Moreover, recent advances that revealed the therapeutic potential of DNPNB enzymes in bacteria could open the road for the pharmacological development of novel antibiotics.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/38444943; pasteur-04520637; https://pasteur.hal.science/pasteur-04520637; https://pasteur.hal.science/pasteur-04520637/document; https://pasteur.hal.science/pasteur-04520637/file/fphar-15-1329011.pdf; PUBMED: 38444943; PUBMEDCENTRAL: PMC10912719
    • الرقم المعرف:
      10.3389/fphar.2024.1329011
    • الدخول الالكتروني :
      https://pasteur.hal.science/pasteur-04520637
      https://pasteur.hal.science/pasteur-04520637/document
      https://pasteur.hal.science/pasteur-04520637/file/fphar-15-1329011.pdf
      https://doi.org/10.3389/fphar.2024.1329011
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.14E80F3