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Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice

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  • معلومة اضافية
    • بيانات النشر:
      MDPI AG
    • الموضوع:
      2015
    • Collection:
      Directory of Open Access Journals: DOAJ Articles
    • نبذة مختصرة :
      All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the intestines were primary targets for it when administered intraperitoneally (i.p.). We performed experiments to assess whether ebulin f administration to six- and 12-month-old mice would trigger higher toxicity than that displayed in six-week-old mice. In the present report, we present evidence indicating that the toxicological effects of ebulin f after its i.p. administration to elderly mice are exerted on the lungs and intestines by an increased rate of apoptosis. We hypothesize that the ebulin f apoptosis-promoting action together with the age-dependent high rate of apoptosis result in an increase in the lectin’s toxicity, leading to a higher lethality level.
    • ISSN:
      2072-6651
    • Relation:
      http://www.mdpi.com/2072-6651/7/2/367; https://doaj.org/toc/2072-6651; https://doaj.org/article/e40551b3543a438f9f27bf4234b9f221
    • الرقم المعرف:
      10.3390/toxins7020367
    • الدخول الالكتروني :
      https://doi.org/10.3390/toxins7020367
      https://doaj.org/article/e40551b3543a438f9f27bf4234b9f221
    • الرقم المعرف:
      edsbas.146D8982