Contributors: 1 Univ Birmingham, Inst Appl Hlth Res, Ctr Childhood Canc Survivor Studies, Birmingham, W Midlands, England Show more 2 Int Agcy Res Canc, Sect Canc Surveillance, Lyon, France Show more 3 INSERM, U1018, Canc & Radiat Team, Villejuif, France 4 Gaslini Children Hosp, Epidemiol & Biostat Sect, Genoa, Italy Show more 5 Semmelweis Univ, Dept Pediat 2, Budapest, Hungary 6 Kepler Univ Klinikum, Linz, Austria 7 Danish Canc Soc, Res Ctr, Survivorship Unit, Copenhagen, Denmark 8 Boyne Res Inst, Drogheda, Ireland 9 Acad Med Ctr, Emma Childrens Hosp, Dept Pediat Oncol, Amsterdam, Netherlands Show more 10 Lund Univ, Skane Univ Hosp, Dept Pediat, Lund, Sweden Show more 11 Univ Med Ctr, German Childhood Canc Registry, Inst Med Biostat Epidemiol & Informat, Mainz, Germany Show more 12 Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland Show more 13 San Gerardo Hosp, Pediat Hematol Unit, Monza, Italy Show more 14 Univ Bern, Swiss Childhood Canc Registry, Inst Social & Prevent Med, Bern, Switzerland
نبذة مختصرة : To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files ; INTRODUCTION: We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors. METHODS: This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated. All statistical tests were two-sided. RESULTS: Overall, survivors were 21.65 times (95% confidence interval = 18.97 to 24.60 times) more likely to be diagnosed with a subsequent primary bone cancer than expected from the general population. The greatest excess numbers of bone cancers were observed after retinoblastoma, bone sarcoma, and soft tissue sarcoma. The excess number of bone cancers declined linearly with both years since diagnosis and attained age (all P < .05). Beyond 40 years from diagnosis and age 40 years, there were at most 0.45 excess bone cancers among all survivors per 10 000 person-years at risk; beyond 30 years from diagnosis and age 30 years, there were at most 5.02 excess bone cancers after each of retinoblastoma, bone sarcoma, and soft tissue sarcoma, per 10 000 person-years at risk. CONCLUSIONS: For all survivors combined and the cancer groups with the greatest excess number of bone cancers, the excess numbers observed declined with both age and years from diagnosis. These results provide novel, reliable, and unbiased information about risks and risk factors among long-term survivors of childhood and adolescent cancer. ; European Union Italian Association for Cancer Research Compagnia San Paolo Fondo Chiara Rama OLUS Swedish Childhood Cancer Foundation Norwegian Childhood Cancer Foundation ...
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