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Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Qing-Lin Li; Hye-Ryeon Kim; Suk-Chul Bae; Kwang Youl Lee; Yoshiaki Ito; Joon Chang; Hoguen Kim; Long Shan Li; Hwan-Mook Kim; Yong Hee Lee; Joong-Kook Choi; Wun-Jae Kim; Kim, Ho Keun; Chang, Joon
    • الموضوع:
      2004
    • نبذة مختصرة :
      RUNX family transcription factors are integral components of TGF-棺 signaling pathways and have been implicated in cell cycle regulation, differentiation, apoptosis, and malignant transformation. It was noted previously that allele loss and loss of expression of RUNX3 are causally involved in gastric carcinogenesis. Our results demonstrate that RUNX3 is inactivated by aberrant DNA methylation in approximately 19% of lung cancer cell lines and 24% of primary lung cancer specimens. RUNX3 methylation is tumor-specific, since it is not observed in surrounding normal lung tissues. Our results suggest that loss of RUNX3 expression by DNA hypermethylation is frequently associated with the evolution of lung cancer. ; open
    • File Description:
      223~228
    • ISSN:
      0006-291X
      1090-2104
    • Relation:
      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; J00281; OAK-2004-01419; https://ir.ymlib.yonsei.ac.kr/handle/22282913/111548; http://www.sciencedirect.com/science/article/pii/S0006291X03026706; T200401670; BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.314(1) : 223-228, 2004
    • الرقم المعرف:
      10.1016/j.bbrc.2003.12.079
    • الدخول الالكتروني :
      https://ir.ymlib.yonsei.ac.kr/handle/22282913/111548
      https://doi.org/10.1016/j.bbrc.2003.12.079
      http://www.sciencedirect.com/science/article/pii/S0006291X03026706
    • Rights:
      CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; not free
    • الرقم المعرف:
      edsbas.1135EC20