Chronic hepatitis C: demographic, disease progression and unstable virological response factors

Chronic hepatitis C – liver inflammation caused by hepatitis C virus. The most common route of infection is parenteral. Chronic hepatitis C is a cause of 35 percent of liver transplantations. Within the last 20 years, the research in LVHC treatment has allowed to better treatment outcomes. The aim of this study is to analyze the demographic, disease progression, and unstable virological response factors. Research tasks: 1) to assess the demographic factors of chronic hepatitis c virus infection; 2) to evaluate unstable virological response factors; 3) to compare treatment results between groups: those treated with interferon and ribavirin and those treated new antiviral drugs. Methods: 143 patients diagnosed with chronic hepatitis C virus were treated in 2011 – 2016. 115 patients were treated with combination of IFN – α and RBV, 28 patients – new antiviral agents. Results: 79 (55,2 %) males and 64 (44,8 %) females. 107 (74,8 %) of patients live in a city. In 73 (50,3 %) of cases, the route of infection was unknown. Prevalence of genotypes: 1a genotype – 8 patients (5,6 %), 1b - 80 (55,9 %), 2 – 7 (4,9 %), 3 - 40 patients (28,0 %). 56 (48,7 %) patients in this first group and 28 (100 %) patients in second group achieve stable virological response. Conclusions: first group patients with small viral load (p=0,044) and second virus genotype (p=0,033) successfully reach SVR. SVR results: 48,7 % treated with IFN – α and RBV, 71,4 % - TVR, 57,1 % – BOC, 100 % – direct antiviral agents.