Prenatalne infekcije i kongenitalne abnormalnosti: vjerojatna povezanost

Moguća povezanost prenatalnih infekcija s raznim kongenitalnim malformacijama istraživana je u 194 novorođenčadi, fetusa te mrtvorođenčadi. Različite izolirane kongenitalne malformacije zabilježene su u 92 djece; u 38 višestruke malformacije te autosomne trisomije u 64. Klinički podaci, povijesti bolesti te protokoli cjelokupne anatomije analizirani su u svih bolesnika. Konzultirani su subspecijalisti, učinjene radiološke i ultrazvučne pretrage te obavljena rutinska klinička praksa kod sve novorođenčadi. PCR analiza korištena je za detekciju virusa rubeole, herpes simpleks tipa 1, citomegalovirusa, Toxoplasma gondii i klamidije trahomatis u uzorcima krvi i urina; te u uzorcima tkiva srca, jetre, mozga, kralježnične moždine, bubrega, pluća te tankog crijeva fiksiranih u formalinu ili uklopljenih u parafin. Prisustvo infektivnog uzročnika dokazano je u 76,1% slučajeva izoliranih kongenitalnih malformacija te u 86,1% višestrukih malformacija. Virus rubeole izoliran je u 58,6% djece s autosomnom trisomijom.
Possible relation of prenatal infections with various congenital malformations was examined in 194 cases including newborns, fetuses, and stillbirths. 92 children had various isolated congenital malformations; 38 – multiple malformations; and 64 – autosomal trisomy. Clinical data, case history and gross anatomy protocols were analyzed for all patients. Subspecialty consultation, radiological and ultrasound examinations have been applied together with routine clinical studies to all newborns. PCR-analysis was used for diagnostics of rubella virus, herpes simplex virus type 1, cytomegalovirus, Toxoplasma gondii and Chlamydia trachomatis in blood and urine samples; and in autopsy formalin-fixed-paraffin-mbedded tissue samples of heart, liver, brain, spinal cord, kidneys, lungs, small intestine. Presence of infectious agents was found in 76.1 % of cases with isolated congenital malformations and in 86.1 % of multiple malformations. Rubella virus was detected in 58.6 % of children with autosomal trisomy.