Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

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المؤلفون: Michael Boehnke; Narisu Narisu; Ryan P. Welch; Christian Fuchsberger; Pasi Soininen; Francis S. Collins; Adam E. Locke; Karen L. Mohlke; Peter S. Chines; Markku Laakso; Xueling Sim; Anne U. Jackson; James P. Davis; Antti J. Kangas; Tanya M. Teslovich; Johanna Kuusisto; Mika Ala-Korpela; Heather M. Stringham; Jeroen R. Huyghe
المصدر:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 10, p e1007079 (2017)
Davis, J P, Huyghe, J R, Locke, A E, Jackson, A U, Sim, X, Stringham, H M, Teslovich, T M, Welch, R P, Fuchsberger, C, Narisu, N, Chines, P S, Kangas, A J, Soininen, P, Ala-Korpela, M, Kuusisto, J, Collins, F S, Laakso, M, Boehnke, M & Mohlke, K L 2017, ' Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study ', PLoS Genetics, vol. 13, no. 10, e1007079 . https://doi.org/10.1371/journal.pgen.1007079
الموضوع:
0301 basic medicine; Exome/genetics; Male; Cancer Research; Principal Component Analysis/methods; Biochemistry; Subclass; chemistry.chemical_compound; Lipid Metabolism/genetics; Gene Frequency; Cell Signaling; Genotype; Exome; European Continental Ancestry Group/genetics; Genetics (clinical); Finland; Phospholipids; Genetics; Principal Component Analysis; Triglycerides/genetics; Middle Aged; Polymorphism, Single Nucleotide/genetics; Lipids; Cholesterol; Gene Frequency/genetics; Lipid Signaling; Genome-Wide Association Study/methods; Lipoproteins/genetics; Genomic Signal Processing; Research Article; Signal Transduction; lcsh:QH426-470; Lipoproteins; Quantitative Trait Loci; Quantitative trait locus; Biology; Polymorphism, Single Nucleotide; White People; 03 medical and health sciences; medicine; Humans; Molecular Biology; Gene; Ecology, Evolution, Behavior and Systematics; Triglycerides; Cholesterol, HDL/genetics; Cholesterol, HDL; Biology and Life Sciences; Proteins; Cell Biology; medicine.disease; Lipid Metabolism; Minor allele frequency; lcsh:Genetics; 030104 developmental biology; chemistry; Lipids/genetics; Genetic Loci; Dyslipidemia; Genome-Wide Association Study
الدخول الالكتروني :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef440e4f0d245ece68b724bb068765f0
https://pubmed.ncbi.nlm.nih.gov/29084231

معلومة اضافية
- Contributors:
  School of Medicine / Clinical Medicine
- الموضوع:
  2017
- نبذة مختصرة :
  Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005
  published version
  peerReviewed
- File Description:
  application/pdf
- ISSN:
  1553-7404
- الرقم المعرف:
  10.1371/journal.pgen.1007079
- Rights:
  OPEN
- الرقم المعرف:
  edsair.doi.dedup.....ef440e4f0d245ece68b724bb068765f0

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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

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