Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Performance limitations of resonant refractive index sensors with low-cost components

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • الموضوع:
      2020
    • نبذة مختصرة :
      Resonant biosensors are attractive for diagnostics because they can detect clinically relevant biomarkers with high sensitivity and in a label-free fashion. Most of the current solutions determine their detection limits in a highly stabilised laboratory environment, which does, however, not apply to real point-of-care applications. Here, we consider the more realistic scenario of low-cost components and an unstabilised environment and consider the related design implications. We find that sensors with lower quality-factor resonances are more fault tolerant, that a filtered LED lightsource is advantageous compared to a diode laser, and that a CMOS camera is preferable to a CCD camera for detection. We exemplify these findings with a guided mode resonance sensor and experimentally determine a limit of detection of 5.8 ± 1.7×10−5 refractive index units (RIU), which is backed up by a model identifying the various noise sources. Our findings will inform the design of high performance, low cost biosensors capable of operating in a real-world environment.
    • File Description:
      application/pdf
    • ISSN:
      1094-4087
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....ebbc96ad840cb5dc04e399888b76684e