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Population level mitogenomics of long-lived bats reveals dynamic heteroplasmy and challenges the Free Radical Theory of Ageing

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  • معلومة اضافية
    • Contributors:
      University College Dublin [Dublin] (UCD); Evolution et Diversité Biologique (EDB); Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3); Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS); Ernst-Moritz-Arndt-Universität Greifswald; Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3); Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
    • بيانات النشر:
      Nature Publishing Group, 2018.
    • الموضوع:
      2018
    • نبذة مختصرة :
      Bats are the only mammals capable of true, powered flight, which drives an extremely high metabolic rate. The “Free Radical Theory of Ageing” (FTRA) posits that a high metabolic rate causes mitochondrial heteroplasmy and the progressive ageing phenotype. Contrary to this, bats are the longest-lived order of mammals given their small size and high metabolic rate. To investigate if bats exhibit increased mitochondrial heteroplasmy with age, we performed targeted, deep sequencing of mitogenomes and measured point heteroplasmy in wild, long lived Myotis myotis. Blood was sampled from 195 individuals, aged between
    • ISSN:
      2045-2322
    • الرقم المعرف:
      10.1038/s41598-018-31093-2
    • الرقم المعرف:
      10.1038/s41598-018-31093-2⟩
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....dfc5bd15e1d4de8e3dcfb7b37d2557a7