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Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis

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  • معلومة اضافية
    • Contributors:
      The institute of cancer research [London]; Yale University [New Haven]; Brigham & Women’s Hospital [Boston] (BWH); Harvard Medical School [Boston] (HMS); Georgia State University; University System of Georgia (USG); Duke University Medical Center; Case Western Reserve University [Cleveland]; Memorial Sloane Kettering Cancer Center [New York]; Keck School of Medicine [Los Angeles]; University of Southern California (USC); National Cancer Institute [Bethesda] (NCI-NIH); National Institutes of Health [Bethesda] (NIH); University of Copenhagen = Københavns Universitet (KU); Mayo Clinic [Rochester]; Umeå University; University of California [San Francisco] (UCSF); University of California; Service de Neurologie [CHU Pitié-Salpêtrière]; IFR70-CHU Pitié-Salpêtrière [AP-HP]; Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM); Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP]; Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS); Sorbonne Université (SU); Baylor College of Medicine (BCM); Baylor University; Service de neurologie 1 [CHU Pitié-Salpétrière]; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP]; Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Gestionnaire, Hal Sorbonne Université; University of Copenhagen = Københavns Universitet (UCPH); University of California [San Francisco] (UC San Francisco); University of California (UC); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Institut du Cerveau = Paris Brain Institute (ICM); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP]; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
    • بيانات النشر:
      Oxford University Press, 2019.
    • الموضوع:
      2019
    • نبذة مختصرة :
      Background The etiological basis of glioma is poorly understood. We have used genetic markers in a Mendelian Randomisation (MR) framework to examine if lifestyle, cardiometabolic and inflammatory factors influence the risk of glioma. This methodology reduces bias from confounding and is not affected by reverse causation. Methods We identified genetic instruments for 37 potentially modifiable risk factors and evaluated their association with glioma risk using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. We used the estimated odds ratio of glioma associated with each of the genetically defined traits to infer evidence for a causal relationship with the following exposures: lifestyle and dietary factors (height, plasma IGF-1, blood carnitine, blood methionine, blood selenium, blood zinc, circulating adiponectin, circulating carotenoids, iron status, serum calcium, vitamin [A1, B12, B6, E and 25-hydroxyvitamin D], fatty acids levels [mono-unsaturated, omega-3 and omega-6] and circulating fetuin-A); cardiometabolic factors (birth weight, HDL cholesterol, LDL cholesterol, total cholesterol, total triglycerides, basal metabolic rate, body fat percentage, body mass index, fasting glucose, fasting proinsulin, HbA1C levels, diastolic and systolic blood pressure, waist circumference, waist-to-hip ratio) were included; inflammatory factors (C-reactive protein (CRP), plasma IL-6 sRa and serum IgE). Results After correction for the testing of multiple potential risk factors and excluding associations driven by one single nucleotide polymorphism (SNP) no significant association with glioma risk was observed (i.e. PCorrected > 0.05). Conclusions This study did not provide evidence supporting any of the 37 factors examined as having a significant influence on glioma risk.
    • File Description:
      application/pdf
    • ISSN:
      1523-5866
      1522-8517
    • الرقم المعرف:
      10.1093/neuonc/noz209⟩
    • الرقم المعرف:
      10.1093/neuonc/noz209
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....dc26ea4a59209164ff0a5170be8de375