Fluoride uptake by dentin surfaces following topical application of TiF4, NaF and fluoride varnishes in vivo

The incorporation and retention of fluoride in exposed dentin surfaces following topical application of TiF4 (1.1 M F, pH 1.0) was compared to the effects of NaF (0.5 M F, pH 7.0) and two fluoride-containing varnishes. Ground dentin surfaces were prepared in anterior teeth of Five beagles. Each dog received a single application of one of the four fluoride agents; the fifth dog was left untreated. 3 weeks later the F, Ti and Ca contents in the experimental dentin surfaces were determined by electron microprobe analysis. The highest F concentrations were found after application of TiF4 and the two F-containing varnishes. The NaF-treated dentin surfaces showed lower F concentrations. In addition, F had permeated much more deeply in TiF4-treated and varnished dentin than in NaF-treated surfaces. A titanium-rich coating had remained on the dentin surface of these specimens. These preliminary results indicate that TiF4 may be an efficient anti-caries topical agent for application to dentin surfaces which have become exposed as a result of abrasion or root planing.