نبذة مختصرة : Background and Objectives: The tendency to use drugs is a growing phenomenon, which is linearly increasing from early adolescence to early adulthood. This study aimed to determine the relationship between religious orientation and addiction potential with the mediatory roles of social support and self-efficacy among male adolescents in Zanjan Rood, Iran. Methods: This descriptive and correlational study was conducted among all male high-school students of Zanjan Rood in the academic year of 2015-2016. In total, 181 subjects were selected based on single-stage cluster sampling. Data collection was carried out using Religious Orientation Scale by Allport, Philips Social Support Questionnaire, Sherer General Self-Efficacy Scale, and Addiction potential Scale (APS). In addition, data analysis was performed through structural equation modeling and path analysis by using SPSS version 20 and LISREL. Results: In this research, the components of internal and external religious orientation, social support (family, friends, acquaintances, and total support), and self-efficacy had a significant impact on addiction potential of the participants. Moreover, social support and self-efficacy had a mediatory role in the relationship between religious orientation and addiction potential among adolescents. Evaluation of direct paths demonstrated that while the path of internal religion orientation had the highest effect on addiction potential (B=0.68, P
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