Antimicrobial susceptibility assessment of compound from Aspergillus fumigatus

Ethyl acetate extract of the culture filtrate of Aspergillus fumigatus on chromatographic analysis has led to the isolation of the compound, AF-1 which exhibited a significant in vitro antimicrobial activity against the tested pathogenic microorganism. The structure of the isolated compound, AF-1 was identified as 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one from its IR, UV, EI-MS, 13 C-NMR, 1 H-NMR, HMBC and HMQC data. This is the first report of the compound, AF-1 from the A. fumigatus. Key words: Aspergillus, 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one, antimicrobial screening, bioactive compound.