Response to the Boucher et al. Comments on Fleury et al. Sun Exposure and Its Effects on Human Health: Mechanisms through Which Sun Exposure Could Reduce the Risk of Developing Obesity and Cardiometabolic Dysfunction. Int. J. Environ. Res. Public Health 2016, 13, 999

We thank Boucher et al. [1] for their interest in our recently published review [2].To directly answer their query [1] regarding calcium homeostasis in our published studies [3],we observed no effect on circulating calcium after feeding male C57BL/6J mice high or low fat dietssupplemented (or not) with vitamin D for 12 weeks ([3], see Figure 5C). However, chronic exposureof mice fed low (but not high) fat diets that were not supplemented with vitamin D to erythemalor sub-erythemal ultraviolet radiation (UVR), significantly reduced circulating calcium levels ([3],see Figure 5C) after 12 weeks of treatment. We are uncertain of the biological effect of these decreasesin circulating calcium as reduced weight gain was observed in mice exposed to erythemal doses, butnot in those exposed to sub-erythemal doses of UVR ([3], see Figure 2). However, it is importantto note that circulating 25-hydroxyvitamin D (25(OH)D) levels remained low (