FLOT2 Promotes the Proliferation and Epithelial-mesenchymal Transition of Cervical Cancer by Activating the MEK/ERK1/2 Pathway

As prevalent cancer in women, approximately 569,847 cases of cervical cancer occur every year.This study aimed to explore the role of FLOT2 and its related mechanism in the development of cervical cancer.Cell culture study and animal experimentation.Quantitative reverse-transcription polymerase chain reaction PCR and Western blot analysis were performed to evaluate the expression of FLOT2. Flow cytometry was applied for the evaluation of cell apoptosis. Cell Counting Kit-8 and colony formation were utilized for proliferation measurement. Cervical cancer mice model was employed to measure the role of FLOT2 in vivo.FLOT2 mRNA and protein levels were dramatically elevated (FLOT2 aggravates the proliferation and epithelialmesenchymal transition of cervical cancer by activating the MEK/ ERK1/2 and AKT pathways.