نبذة مختصرة : This study aimed to evaluate the clinical application of the preoperative prealbumin-to-fibrinogen ratio (PFR) in the clinical diagnosis of hepatocellular carcinoma (HCC) patients and its prognostic value.The clinical and laboratory data of 269 HCC patients undergoing surgical treatment from January 2012 to January 2017 in Taizhou Hospital were retrospectively analysed. The Cox regression model was used to analyse the correlation between the PFR and other clinicopathological factors in overall survival (OS) and disease-free survival (DFS).Cox regression analysis showed that the PFR (hazard ratio (HR)=2.123; 95% confidence interval (95% CI), 1.271-3.547; P=0.004) was an independent risk factor affecting the OS of HCC patients. Furthermore, a nomogram was built based on these risk factors. The C-index for the OS nomogram was 0.715.Nomograms based on the PFR can be recommended as the correct and actual model to evaluate the prognosis of patients with HCC.Cilj ove studije je bio da proceni kliničku primenu preoperativnog odnosa prealbumin-fibrinogena (PFR) u kliničkoj dijagnozi pacijenata sa hepatocelularnim karcinomom (HCC) i njegovu prognostičku vrednost.Sprovedena je retrospektivna analiza kliničkih i laboratorijskih podataka 269 pacijenata sa HCC koji su bili na hirurškom lečenju od januara 2012. do januara 2017. u Taizhou bolnici. Za analizu korelacije između PFR-a i drugih kliničko-patoloških faktora u ukupnom preživljavanju (OS) i preživljavanju bez bolesti (DFS) korišćen je Koksov regresioni model.Koksova regresiona analiza je pokazala da je PFR (indeks rizika (HR) = 2,123; 95% interval pouzdanosti (95% CI), 1,271-3,547; P = 0,004) bio nezavisni faktor rizika koji je uticao na ukupno preživljavanje pacijenata sa HCC. Dodatno, na osnovu ovih faktora rizika je urađen nomogram. C-indeks za nomogram ukupnog preživljavanja je bio 0,715.Nomogrami zasnovani na PFR-u se mogu preporučiti kao ispravan i stvarni model za procenu prognoze kod pacijenata sa HCC.
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