Common variants associated with plasma triglycerides and risk for coronary artery disease

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المؤلفون: Richard S. Cooper; Angela Döring; Cisca Wijmenga; Jerome I. Rotter; Linda S. Adair; Tõnu Esko; Jennifer L. Bragg-Gresham; Danish Saleheen; Narisu Narisu; Xiaohui Li; Kathleen Stirrups; Ulf de Faire; Nicholas G. Martin; Dmitry Shungin; Peter Vollenweider; Yii-Der Ida Chen; Dharambir K. Sanghera; George Dedoussis; Toshiko Tanaka; Manjinder S. Sandhu; Anne U. Jackson; Nancy L. Pedersen; Maria Dimitriou; Shih-Yi Lin; David P. Strachan; Isleifur Olafsson; Ruth J. F. Loos; Kay-Tee Khaw; Antero Kesäniemi; Rainer Rauramaa; Wendy L. McArdle; Gonneke Willemsen; Dena G. Hernandez; May E. Montasser; Amy J. Swift; Colin A. McKenzie; Aaron Isaacs; Latonya F. Been; Leif Groop; Massimo Mangino; Martina Müller-Nurasyid; Karen L. Mohlke; Ci Song; Sailaja Vedantam; Anna-Liisa Hartikainen; Lori L. Bonnycastle; Ilja M. Nolte; Jaakko Kaprio; Anneli Pouta; Unnur Thorsteinsdottir; Paul Elliott; Muredach P. Reilly; Jean Ferrières; Daniel J. Rader; Elizabeth H. Young; Jaspal S. Kooner; Leena Moilanen; Markku Laakso; Albert Hofman; Kelly A. Volcik; Sekar Kathiresan; Tamara B. Harris; Eric Kim; Aimo Ruokonen; Andrea Ganna; Serena Sanna; John J.P. Kastelein; Martha L. Gravito; Ronald M. Krauss; Ken K. Ong; Paul M. Ridker; Kristian Hveem; Ayse Demirkan; Alena Stančáková; Pierre Meneton; Thomas Quertermous; John Danesh; Toby Johnson; Cornelia M. van Duijn; Samuli Ripatti; Christopher J. Groves; Jaakko Tuomilehto; Michael Boehnke; Jose M. Ordovas; Alan B. Feranil; Chao A. Hsiung; Wayne Huey-Herng Sheu; Igor Rudan; Christa Meisinger; Rebecca N. Nsubuga; Bruna Gigante; Inger Njølstad; Göran Hallmans; Aroon D. Hingorani; Jouko Saramies; Deepti Gurdasani; Fernando Rivadeneira; Andres Metspalu; Stephen E. Epstein; Gonçalo R. Abecasis; Braxton D. Mitchell; Devin Absher; Marcus E. Kleber; Sonia Shah; Pierre Fontanillas; Jeffrey R. O'Connell; Louise A. Donnelly; Jing Hua Zhao; Martin L. Buchkovich; Francis S. Collins; Gabrielle Müller; Matti Uusitupa; Evelin Mihailov; Nicholas J. Wareham; Andrew A. Hicks; Dorret I. Boomsma; Harry Campbell; Ellen M. Schmidt; Jaana Lindström; Mark I. McCarthy; Evita G. Van Den Herik; Kirsten Ohm Kyvik; Vilmundur Gudnason; Jackie F. Price; Joel N. Hirschhorn; Winfried März; Aravinda Chakravarti; Pontiano Kaleebu; James F. Wilson; Lindsay L. Waite; Leo-Pekka Lyytikäinen; Sebanti Sengupta; Mika Kivimäki; David Altshuler; Hilma Holm; Rona J. Strawbridge; Harald Grallert; Ramaiah Nagaraja; Laurence Tiret; G. Kees Hovingh; Meena Kumari; Nilesh J. Samani; Daniel F. Freitag; Nelson B. Freimer; Thomas Illig; Panos Deloukas; Bernhard O. Boehm; Nicholas W.J. Wainwright; Mark J. Daly; Mika Kähönen; Michel Burnier; Norman Klopp; L. Adrienne Cupples; Aarno Palotie; Markus Perola; Bamidele O. Tayo; Timo A. Lakka; Matthew Jones; Sarah H. Wild; Patricia B. Munroe; Antti Jula; François Mach; Peter J. Koudstaal; Pirjo Komulainen; Eric Boerwinkle; L. Joost van Pelt; Veikko Salomaa; Ann-Kristin Petersen; Ida Surakka; Andrew Wong; Caroline Hayward; Chi Gao; Cristen J. Willer; Stephen S. Rich; Yi Jen Hung; Peter P. Pramstaller; Diana Kuh; Ron Do; Dominique Arveiler; Mark O. Goodarzi; Ross M. Fraser; Ingrid B. Borecki; Steven C. Hunt; Weihua Zhang; Mary Susan Burnett; Patrik K. E. Magnusson; John C. Chambers; Benjamin M. Neale; Peter Schwarz; Jennifer L. Bolton; Murielle Bochud; Heleen M. den Hertog; Christian Gieger; Cristina Pomilla; Teresa Ferreira; Lars Wallentin; Richa Saxena; André G. Uitterlinden; Kaisa Silander; Ying Wu; Bruce M. Psaty; Jian'an Luan; Hsing-Yi Chang; Jin Chen; Daniel I. Chasman; Ulf Gyllensten; Kari Stefansson; Kauko Heikkilä; Tom Wilsgaard; Alan R. Shuldiner; Carlos Iribarren; Stavroula Kanoni; John Whitfield; Gershim Asiki; Marika Kaakinen; Georg Ehret; Elina Hyppönen; Claudia Langenberg; Gina M. Peloso; Cecilia M. Lindgren; Carlo Sidore; Gudmundur I. Eyjolfsson; Cameron D. Palmer; Jacques S. Beckmann; Hubert Scharnagl; Tanya M. Teslovich; Mary F. Feitosa; Terho Lehtimäki; Steve E. Humphries; Chris Power; Benjamin F. Voight; Stefania Bandinelli; Andrew D. Morris; Gudmar Thorleifsson; Tuomo Nieminen; Tim D. Spector; Paul W. Franks; Themistocles L. Assimes; Pascal Bovet; Luigi Ferrucci; Johannes Kettunen; Inês Barroso; Franklyn I. Bennett; Stefan Gustafsson; Paolo Brambilla; Theodore Papamarkou; Elena Tremoli; Janet Seeley; Alex S. F. Doney; Johanna Kuusisto; Giancarlo Cesana; Bruce H. R. Wolffenbuttel; Lars Lind; Stefan R. Bornstein; Åsa Johansson; Anders Hamsten; Marjo-Riitta Järvelin; Krista Fischer; Agneta Siegbahn; Samia Mora; Erik Ingelsson; Colin N. A. Palmer
المصدر:
Nature Genetics, 45(11), 1345-1352. Nature Publishing Group
Do, R, Willer, C J, Schmidt, E M, Sengupta, S, Gao, C, Peloso, G M, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, M L, Mora, S, Beckmann, J S, Bragg-Gresham, J L, Chang, H Y, Demirkan, A, den Hertog, H M, Donnelly, L A, Ehret, G B, Esko, T, Feitosa, M F, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, R M, Freitag, D F, Gurdasani, D, Heikkilä, K, Hyppönen, E, Isaacs, A, Jackson, A U, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, M E, Li, X, Luan, J, Lyytikäinen, L P, Magnusson, P K, Mangino, M, Mihailov, E, Montasser, M E, Müller-Nurasyid, M, Nolte, I M, O'Connell, J R, Palmer, C D, Perola, M, Petersen, A K, Sanna, S, Saxena, R, Service, S K, Shah, S, Shungin, D, Sidore, C, Song, C, Strawbridge, R J, Surakka, I, Tanaka, T, Teslovich, T M, Thorleifsson, G, van den Herik, E G, Voight, B F, Volcik, K A, Waite, L L, Wong, A, Wu, Y, Zhang, W, Absher, D, Asiki, G, Barroso, I, Been, L F, Bolton, J L, Bonnycastle, L L, Brambilla, P, Burnett, M S, Cesana, G, Dimitriou, M, Doney, A S F, Döring, A, Elliott, P, Epstein, S E, Eyjolfsson, G I, Gigante, B, Goodarzi, M O, Grallert, H, Gravito, M L, Groves, C J, Hallmans, G, Hartikainen, A L, Hayward, C, Hernandez, D, Hicks, A A, Holm, H, Hung, Y J, Illig, T, Jones, M R, Kaleebu, P, Kastelein, J J, Khaw, K T, Kim, E, Klopp, N, Komulainen, P, Kumari, M, Langenberg, C, Lehtimäki, T, Lin, S Y, Lindström, J, Loos, R J, Mach, F, McArdle, W L, Meisinger, C, Mitchell, B D, Müller, G, Nagaraja, R, Narisu, N, Nieminen, T V, Nsubuga, R N, Olafsson, I, Ong, K K, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Rader, D J, Reilly, M P, Ridker, P M, Rivadeneira, F, Rudan, I, Ruokonen, A, Samani, N J, Scharnagl, H, Seeley, J, Silander, K, Stancakova, A, Stirrups, K, Swift, A J, Tiret, L, Uitterlinden, A G, van Pelt, L J, Vedantam, S, Wainwright, N W, Wijmenga, C, Wild, S H, Willemsen, G, Wilsgaard, T, Wilson, J F, Young, E H, Zhao, J H, Adair, L S, Arveiler, D, Assimes, T L, Bandinelli, S, Bennett, F, Bochud, M, Boehm, B O, Boomsma, D I, Borecki, I B, Bornstein, S R, Bovet, P, Burnier, M, Campbell, H, Chakravarti, A, Chambers, J C, Chen, Y D, Collins, F S, Cooper, R S, Danesh, J, Dedoussis, G, de Faire, U, Feranil, A B, Ferrières, J, Ferrucci, L, Freimer, N B, Gieger, C, Groop, L C, Gudnason, V, Gyllensten, U, Hamsten, A, Harris, T B, Hingorani, A D, Hirschhorn, J N, Hofman, A, Hovingh, K G, Hsiung, C A, Humphries, S E, Hunt, S C, Hveem, K, Iribarren, C, Järvelin, M R, Jula, A, Kähönen, M, Kaprio, J, Kesäniemi, A, Kivimaki, M, Kooner, J S, Koudstaal, P J, Krauss, R M, Kuh, D, Kuusisto, J, Kyvik, K O, Laakso, M, Lakka, T A, Lind, L, Lindgren, C M, Martin, N G, März, W, McCarthy, M I, McKenzie, C A, Meneton, P, Metspalu, A, Moilanen, L, Morris, A D, Munroe, P B, Njolstad, I, Pedersen, N L, Power, C, Pramstaller, P P, Price, J F, Psaty, B M, Quertermous, T, Rauramaa, R, Saleheen, D, Salomaa, V, Sanghera, D K, Saramies, J, Schwarz, P E, Sheu, W H, Shuldiner, A R, Siegbahn, A, Spector, T D, Stefansson, K, Strachan, D P, Tayo, B O, Tremoli, E, Tuomilehto, J, Uusitupa, M, van Duijn, C M, Vollenweider, P, Wallentin, L, Wareham, N J, Whitfield, J B, Wolffenbuttel, B H, Altshuler, D, Ordovas, J M, Boerwinkle, E, Palmer, C N, Thorsteinsdottir, U, Chasman, D I, Rotter, J I, Franks, P W, Ripatti, S, Cupples, L A, Sandhu, M S, Rich, S S, Boehnke, M, Deloukas, P, Mohlke, K L, Ingelsson, E, Abecasis, G R, Daly, M J, Neale, B M & Kathiresan, S 2013, ' Common variants associated with plasma triglycerides and risk for coronary artery disease ', Nature Genetics, vol. 45, no. 11, pp. 1345-1352 . https://doi.org/10.1038/ng.2795
Do, R, Willer, C J, Schmidt, E M, Sengupta, S, Gao, C, Peloso, G M, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, M L, Mora, S, Beckmann, J S, Bragg-Gresham, J L, Chang, H Y, Demirkan, A, Den Hertog, H M, Donnelly, L A, Ehret, G B, Esko, T, Feitosa, M F, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, R M, Freitag, D F, Gurdasani, D, Heikkila, K, Hypponen, E, Isaacs, A, Jackson, A U, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, M E, Li, X H, Luan, J A, Lyytikainen, L P, Magnusson, P K E, Mangino, M, Mihailov, E, Montasser, M E, Muller-Nurasyid, M, Nolte, I M, O'Connell, J R, Palmer, C D, Perola, M, Petersen, A K, Sanna, S, Saxena, R, Service, S K, Shah, S, Shungin, D, Sidore, C, Song, C, Strawbridge, R J, Surakka, I, Tanaka, T, Teslovich, T M, Thorleifsson, G, Van den Herik, E G, Voight, B F, Volcik, K A, Waite, L L, Wong, A, Wu, Y, Zhang, W H, Absher, D, Asiki, G, Barroso, I, Been, L F, Bolton, J L, Bonnycastle, L L, Brambilla, P, Burnett, M S, Cesana, G, Dimitriou, M, Doney, A S F, Doring, A, Elliott, P, Epstein, S E, Eyjolfsson, G I, Gigante, B, Goodarzi, M O, Grallert, H, Gravito, M L, Groves, C J, Hallmans, G, Hartikainen, A L, Hayward, C, Hernandez, D, Hicks, A A, Holm, H, Hung, Y J, Illig, T, Jones, M R, Kaleebu, P, Kastelein, J J P, Khaw, K T, Kim, E, Klopp, N, Komulainen, P, Kumari, M, Langenberg, C, Lehtimaki, T, Lin, S Y, Lindstrom, J, Loos, R J F, Mach, F, McArdle, W L, Meisinger, C, Mitchell, B D, Muller, G, Nagaraja, R, Narisu, N, Nieminen, T V M, Nsubuga, R N, Olafsson, I, Ong, K K, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Rader, D J, Reilly, M P, Ridker, P M, Rivadeneira, F, Rudan, I, Ruokonen, A, Samani, N, Scharnagl, H, Seeley, J, Silander, K, Stancakova, A, Stirrups, K, Swift, A J, Tiret, L, Uitterlinden, A G, van Pelt, L J, Vedantam, S, Wainwright, N, Wijmenga, C, Wild, S H, Willemsen, G, Wilsgaard, T, Wilson, J F, Young, E H, Zhao, J H, Adair, L S, Arveiler, D, Assimes, T L, Bandinelli, S, Bennett, F, Bochud, M, Boehm, B O, Boomsma, D I, Borecki, I B, Bornstein, S R, Bovet, P, Burnier, M, Campbell, H, Chakravarti, A, Chambers, J C, Chen, Y D I, Collins, F S, Cooper, R S, Danesh, J, Dedoussis, G, de Faire, U, Feranil, A B, Ferrieres, J, Ferrucci, L, Freimer, N B, Gieger, C, Groop, L C, Gudnason, V, Gyllensten, U, Hamsten, A, Harris, T B, Hingorani, A, Hirschhorn, J N, Hofman, A, Hovingh, G K, Hsiung, C A, Humphries, S E, Hunt, S C, Hveem, K, Iribarren, C, Jarvelin, M R, Jula, A, Kahonen, M, Kaprio, J, Kesaniemi, A, Kivimaki, M, Kooner, J S, Koudstaal, P J, Krauss, R M, Kuh, D, Kuusisto, J, Kyvik, K O, Laakso, M, Lakka, T A, Lind, L, Lindgren, C M, Martin, N G, Marz, W, McCarthy, M I, McKenzie, C A, Meneton, P, Metspalu, A, Moilanen, L, Morris, A D, Munroe, P B, Njolstad, I, Pedersen, N L, Power, C, Pramstaller, P P, Price, J F, Psaty, B M, Quertermous, T, Rauramaa, R, Saleheen, D, Salomaa, V, Sanghera, D K, Saramies, J, Schwarz, P E H, Sheu, W H H, Shuldiner, A R, Siegbahn, A, Spector, T D, Stefansson, K, Strachan, D P, Tayo, B O, Tremoli, E, Tuomilehto, J, Uusitupa, M, van Duijn, C M, Vollenweider, P, Wallentin, L, Wareham, N J, Whitfield, J B, Wolffenbuttel, B H R, Altshuler, D, Ordovas, J M, Boerwinkle, E, Palmer, C N A, Thorsteinsdottir, U, Chasman, D I, Rotter, J I, Franks, P W, Ripatti, S, Cupples, L A, Sandhu, M S, Rich, S S, Boehnke, M, Deloukas, P, Mohlke, K L, Ingelsson, E, Abecasis, G R, Daly, M J, Neale, B M & Kathiresan, S 2013, ' Common variants associated with plasma triglycerides and risk for coronary artery disease ', Nature Genetics, vol. 45, pp. 1345-1352 . https://doi.org/10.1038/ng.2795
Nature genetics, 45(11), 1345-1352. Nature Publishing Group
Nature Genetics, 45(11), 1345-52. Nature Publishing Group
NATURE GENETICS
Nature genetics
Nature Genetics, 45(11), 1345-+. Nature Publishing Group
Do, R, Willer, C J, Schmidt, E M, Sengupta, S, Gao, C, Peloso, G M, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, M L, Mora, S, Beckmann, J S, Bragg-Gresham, J L, Chang, H-Y, Demirkan, A, Den Hertog, H M, Donnelly, L A, Ehret, G B, Esko, T, Feitosa, M F, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, R M, Freitag, D F, Gurdasani, D, Heikkilä, K, Hyppönen, E, Isaacs, A, Jackson, A U, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, M E, Li, X, Luan, J, Lyytikäinen, L-P, Magnusson, P K E, Mangino, M, Mihailov, E, Montasser, M E, Müller-Nurasyid, M, Nolte, I M, O'Connell, J R, Palmer, C D, Perola, M, Petersen, A-K, Sanna, S, Saxena, R, Service, S K, Shah, S, Shungin, D, Sidore, C, Song, C, Strawbridge, R J, Surakka, I, Tanaka, T, Teslovich, T M, Thorleifsson, G, Van den Herik, E G, Voight, B F, Volcik, K A, Waite, L L, Wong, A, Wu, Y, Zhang, W, Absher, D, Asiki, G, Barroso, I, Been, L F, Bolton, J L, Bonnycastle, L L, Brambilla, P, Burnett, M S, Cesana, G, Dimitriou, M, Doney, A S F, Döring, A, Elliott, P, Epstein, S E, Eyjolfsson, G I, Gigante, B, Goodarzi, M O, Grallert, H, Gravito, M L, Groves, C J, Hallmans, G, Hartikainen, A-L, Hayward, C, Hernandez, D, Hicks, A A, Holm, H, Hung, Y-J, Illig, T, Jones, M R, Kaleebu, P, Kastelein, J J P, Khaw, K-T, Kim, E, Klopp, N, Komulainen, P, Kumari, M, Langenberg, C, Lehtimäki, T, Lin, S-Y, Lindström, J, Loos, R J F, Mach, F, McArdle, W L, Meisinger, C, Mitchell, B D, Müller, G, Nagaraja, R, Narisu, N, Nieminen, T V M, Nsubuga, R N, Olafsson, I, Ong, K K, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Rader, D J, Reilly, M P, Ridker, P M, Rivadeneira, F, Rudan, I, Ruokonen, A, Samani, N, Scharnagl, H, Seeley, J, Silander, K, Stančáková, A, Stirrups, K, Swift, A J, Tiret, L, Uitterlinden, A G, van Pelt, L J, Vedantam, S, Wainwright, N, Wijmenga, C, Wild, S H, Willemsen, G, Wilsgaard, T, Wilson, J F, Young, E H, Zhao, J H, Adair, L S, Arveiler, D, Assimes, T L, Bandinelli, S, Bennett, F, Bochud, M, Boehm, B O, Boomsma, D I, Borecki, I B, Bornstein, S R, Bovet, P, Burnier, M, Campbell, H, Chakravarti, A, Chambers, J C, Chen, Y-D I, Collins, F S, Cooper, R S, Danesh, J, Dedoussis, G, de Faire, U, Feranil, A B, Ferrières, J, Ferrucci, L, Freimer, N B, Gieger, C, Groop, L C, Gudnason, V, Gyllensten, U, Hamsten, A, Harris, T B, Hingorani, A, Hirschhorn, J N, Hofman, A, Hovingh, G K, Hsiung, C A, Humphries, S E, Hunt, S C, Hveem, K, Iribarren, C, Järvelin, M-R, Jula, A, Kähönen, M, Kaprio, J, Kesäniemi, A, Kivimaki, M, Kooner, J S, Koudstaal, P J, Krauss, R M, Kuh, D, Kuusisto, J, Kyvik, K O, Laakso, M, Lakka, T A, Lind, L, Lindgren, C M, Martin, N G, März, W, McCarthy, M I, McKenzie, C A, Meneton, P, Metspalu, A, Moilanen, L, Morris, A, Munroe, P B, Njølstad, I, Pedersen, N L, Power, C, Pramstaller, P P, Price, J F, Psaty, B M, Quertermous, T, Rauramaa, R, Saleheen, D, Salomaa, V, Sanghera, D K, Saramies, J, Schwarz, P E H, Sheu, W H-H, Shuldiner, A R, Siegbahn, A, Spector, T D, Stefansson, K, Strachan, D P, Tayo, B O, Tremoli, E, Tuomilehto, J, Uusitupa, M, van Duijn, C M, Vollenweider, P, Wallentin, L, Wareham, N J, Whitfield, J B, Wolffenbuttel, B H R, Altshuler, D, Ordovas, J M, Boerwinkle, E, Palmer, C N A, Thorsteinsdottir, U, Chasman, D I, Rotter, J I, Franks, P W, Ripatti, S, Cupples, L A, Sandhu, M S, Rich, S S, Boehnke, M, Deloukas, P, Mohlke, K L, Ingelsson, E, Abecasis, G R, Daly, M J, Neale, B M & Kathiresan, S 2013, ' Common variants associated with plasma triglycerides and risk for coronary artery disease ', Nature Genetics, vol. 45, no. 11, pp. 1345-52 . https://doi.org/10.1038/ng.2795
Nature Genetics, vol. 45, no. 11, pp. 1345-1352
الموضوع:
Netherlands Twin Register (NTR); BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA; Heart disease; Genome-wide association study; Coronary Artery Disease; 030204 cardiovascular system & hematology; ISCHEMIC-HEART-DISEASE; Triglyceride; Coronary artery disease; chemistry.chemical_compound; 0302 clinical medicine; High-density lipoprotein; Polymorphism (computer science); Risk Factors; High-density-lipoprotein; Genetic epidemiology; 11 Medical and Health Sciences; Genetics & Heredity; 0303 health sciences; Cholesterol, HDL/blood; Cholesterol levels; Loci; Contribute; Single Nucleotide; LDL/blood; Triglycerides/blood; Cholesterol; Cholesterol, LDL/blood; HDL/blood; lipids (amino acids, peptides, and proteins); Life Sciences & Biomedicine; Human; medicine.medical_specialty; TYPE-2 DIABETES-MELLITUS; Biology; Polymorphism, Single Nucleotide; Article; HIGH-DENSITY-LIPOPROTEIN ISCHEMIC-HEART-DISEASE TYPE-2 DIABETES-MELLITUS MENDELIAN RANDOMIZATION CARDIOVASCULAR-DISEASE GENETIC EPIDEMIOLOGY CHOLESTEROL LEVELS LOCI CONTRIBUTE THERAPY; 03 medical and health sciences; Coronary Artery Disease/blood; SDG 3 - Good Health and Well-being; Cardiovascular-disease; Internal medicine; Mendelian randomization; Genetics; medicine; Humans; Polymorphism; plasma; Triglycerides; 030304 developmental biology; Science & Technology; Risk Factor; Cholesterol, HDL; Biological Transport; Cholesterol, LDL; 06 Biological Sciences; medicine.disease; Heart-disease; lipoproteins; Endocrinology; chemistry; Therapy; Developmental Biology
اللغة:
English
الدخول الالكتروني :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60180b29952018652b9e9ce418650a3
https://doi.org/10.1038/ng.2795

معلومة اضافية
- Contributors:
  ACS - Amsterdam Cardiovascular Sciences; Vascular Medicine; Life Course Epidemiology (LCE); Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI); Lifestyle Medicine (LM); Center for Liver, Digestive and Metabolic Diseases (CLDM); Epidemiology; Surgery; Public Health; Ophthalmology; Neurology; Medical Microbiology & Infectious Diseases; Obstetrics & Gynecology; Internal Medicine; Do, Ron; Willer, Cristen J; Schmidt, Ellen M; Sengupta, Sebanti; Hyppönen, Elina; Kathiresan, Sekar; Biological Psychology; EMGO+ - Lifestyle, Overweight and Diabetes; Do, R; Willer, C; Schmidt, E; Sengupta, S; Gao, C; Peloso, G; Gustafsson, S; Kanoni, S; Ganna, A; Chen, J; Buchkovich, M; Mora, S; Beckmann, J; Bragg Gresham, J; Chang, H; Demirkan, A; Den Hertog, H; Donnelly, L; Ehret, G; Esko, T; Feitosa, M; Ferreira, T; Fischer, K; Fontanillas, P; Fraser, R; Freitag, D; Gurdasani, D; Heikkilä, K; Hyppönen, E; Isaacs, A; Jackson, A; Johansson, A; Johnson, T; Kaakinen, M; Kettunen, J; Kleber, M; Li, X; Luan, J; Lyytikäinen, L; Magnusson, P; Mangino, M; Mihailov, E; Montasser, M; Müller Nurasyid, M; Nolte, I; O'Connell, J; Palmer, C; Perola, M; Petersen, A; Sanna, S; Saxena, R; Service, S; Shah, S; Shungin, D; Sidore, C; Song, C; Strawbridge, R; Surakka, I; Tanaka, T; Teslovich, T; Thorleifsson, G; Van den Herik, E; Voight, B; Volcik, K; Waite, L; Wong, A; Wu, Y; Zhang, W; Absher, D; Asiki, G; Barroso, I; Been, L; Bolton, J; Bonnycastle, L; Brambilla, P; Burnett, M; Cesana, G; Dimitriou, M; Doney, A; Döring, A; Elliott, P; Epstein, S; Eyjolfsson, G; Gigante, B; Goodarzi, M; Grallert, H; Gravito, M; Groves, C; Hallmans, G; Hartikainen, A; Hayward, C; Hernandez, D; Hicks, A; Holm, H; Hung, Y; Illig, T; Jones, M; Kaleebu, P; Kastelein, J; Khaw, K; Kim, E; Klopp, N; Komulainen, P; Kumari, M; Langenberg, C; Lehtimäki, T; Lin, S; Lindström, J; Loos, R; Mach, F; Mcardle, W; Meisinger, C; Mitchell, B; Müller, G; Nagaraja, R; Narisu, N; Nieminen, T; Nsubuga, R; Olafsson, I; Ong, K; Palotie, A; Papamarkou, T; Pomilla, C; Pouta, A; Rader, D; Reilly, M; Ridker, P; Rivadeneira, F; Rudan, I; Ruokonen, A; Samani, N; Scharnagl, H; Seeley, J; Silander, K; Stančáková, A; Stirrups, K; Swift, A; Tiret, L; Uitterlinden, A; van Pelt, L; Vedantam, S; Wainwright, N; Wijmenga, C; Wild, S; Willemsen, G; Wilsgaard, T; Wilson, J; Young, E; Zhao, J; Adair, L; Arveiler, D; Assimes, T; Bandinelli, S; Bennett, F; Bochud, M; Boehm, B; Boomsma, D; Borecki, I; Bornstein, S; Bovet, P; Burnier, M; Campbell, H; Chakravarti, A; Chambers, J; Chen, Y; Collins, F; Cooper, R; Danesh, J; Dedoussis, G; de Faire, U; Feranil, A; Ferrières, J; Ferrucci, L; Freimer, N; Gieger, C; Groop, L; Gudnason, V; Gyllensten, U; Hamsten, A; Harris, T; Hingorani, A; Hirschhorn, J; Hofman, A; Hovingh, G; Hsiung, C; Humphries, S; Hunt, S; Hveem, K; Iribarren, C; Järvelin, M; Jula, A; Kähönen, M; Kaprio, J; Kesäniemi, A; Kivimaki, M; Kooner, J; Koudstaal, P; Krauss, R; Kuh, D; Kuusisto, J; Kyvik, K; Laakso, M; Lakka, T; Lind, L; Lindgren, C; Martin, N; März, W; Mccarthy, M; Mckenzie, C; Meneton, P; Metspalu, A; Moilanen, L; Morris, A; Munroe, P; Njølstad, I; Pedersen, N; Power, C; Pramstaller, P; Price, J; Psaty, B; Quertermous, T; Rauramaa, R; Saleheen, D; Salomaa, V; Sanghera, D; Saramies, J; Schwarz, P; Sheu, W; Shuldiner, A; Siegbahn, A; Spector, T; Stefansson, K; Strachan, D; Tayo, B; Tremoli, E; Tuomilehto, J; Uusitupa, M; van Duijn, C; Vollenweider, P; Wallentin, L; Wareham, N; Whitfield, J; Wolffenbuttel, B; Altshuler, D; Ordovas, J; Boerwinkle, E; Thorsteinsdottir, U; Chasman, D; Rotter, J; Franks, P; Ripatti, S; Cupples, L; Sandhu, M; Rich, S; Boehnke, M; Deloukas, P; Mohlke, K; Ingelsson, E; Abecasis, G; Daly, M; Neale, B; Kathiresan, S
- بيانات النشر:
  Nature Publishing Group, 2013.
- الموضوع:
  2013
- نبذة مختصرة :
  Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10 -8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD. © 2013 Nature America, Inc. All rights reserved.
- File Description:
  application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document; STAMPA
- ISSN:
  1546-1718
  1061-4036
- Rights:
  OPEN
- الرقم المعرف:
  edsair.doi.dedup.....a60180b29952018652b9e9ce418650a3

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Common variants associated with plasma triglycerides and risk for coronary artery disease

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