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Progression of cognitive and behavioural impairment in early amyotrophic lateral sclerosis

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  • معلومة اضافية
    • Contributors:
      Projectafdeling ALS; ZL Neuromusculaire Ziekten Medisch; Brain; Regenerative Medicine and Stem Cells
    • بيانات النشر:
      BMJ, 2020.
    • الموضوع:
      2020
    • نبذة مختصرة :
      Whether cognitive and behavioural impairment in amyotrophic lateral sclerosis (ALS) is progressive is unknown. The majority of longitudinal studies (summarised in online supplementary material) are characterised by stable test results, high attrition and under-representation of patients with a short disease duration.1 2 The aim of this study was to determine progression of cognitive and behavioural impairment in patients with early symptomatic ALS. ### Supplementary data [jnnp-2020-322992supp001.pdf] At our tertiary ALS clinics, we consecutively recruited patients with ALS with a short disease duration (3 abnormal tests (including letter fluency, and either two executive or two language tests, as described above).3 We used the ALS-FTD-Questionnaire (ALS-FTD-Q) to subdivide patients into groups with ‘no’ (
    • File Description:
      application/pdf
    • ISSN:
      1468-330X
      0022-3050
    • الرقم المعرف:
      10.1136/jnnp-2020-322992
    • Rights:
      CC BY
      URL: http://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: http://creativecommons.org/licenses/by/4.0/.
    • الرقم المعرف:
      edsair.doi.dedup.....8b00f88b52fd55b604b5c0b79d9e511b