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Effect of Moxifloxacin Combined with Cefotaxime Compared to Cefotaxime-Gentamicin Combination on Prevention of White Matter Damage Associated with Escherichia coli Sepsis in Neonatal Rats

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  • معلومة اضافية
    • Contributors:
      Réanimation et Pédiatrie Néonatales; Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7); Neurobiologie des processus adaptatifs (NPA); Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC); AP-HP Hôpital universitaire Robert-Debré [Paris]; Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Centre de référence Maladies Métaboliques; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7); Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS); Cancer, Inflammation, Hormones; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Centre de référence Maladies Métaboliques; Institut National de la Santé et de la Recherche Médicale (INSERM)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
    • بيانات النشر:
      HAL CCSD, 2011.
    • الموضوع:
      2011
    • نبذة مختصرة :
      Relative to the cefotaxime-gentamicin combination, the moxifloxacin-cefotaxime combination significantly reduced microglial activation and immature oligodendrocyte cell death and delayed myelination in the developing white matter of neonatal rats with experimental Escherichia coli sepsis. These neuroprotective effects were not due to differences in in vivo bactericidal activities or in the systemic inflammatory responses and could be related to the intrinsic immunomodulatory properties of moxifloxacin. Molecular mechanisms underlying the neuroprotective effect of moxifloxacin remain to be elucidated.
    • ISSN:
      0066-4804
      1098-6596
    • الرقم المعرف:
      10.1128/AAC.01813-10⟩
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....8857dabde7638417e0ec5d5561a34b0d