Contributors: Fusco, Roberta; Granata, Vincenza; Sansone, Mario; Rega, Daniela; Delrio, Paolo; Tatangelo, Fabiana; Romano, Carmen; Avallone, Antonio; Pupo, Davide; Giordano, Marzia; Grassi, Roberto; Ravo, Vincenzo; Pecori, Biagio; Petrillo, Antonella; Fusco, R.; Granata, V.; Sansone, M.; Rega, D.; Delrio, P.; Tatangelo, F.; Romano, C.; Avallone, A.; Pupo, D.; Giordano, M.; Grassi, R.; Ravo, V.; Pecori, B.; Petrillo, A.
نبذة مختصرة : Purpose: Standardized index of shape (SIS) tool validation to examine dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in preoperative chemo-radiation therapy (pCRT) assessment of locally advanced rectal cancer (LARC) in order to guide the surgeon versus more or less conservative treatment. Materials and methods: A total of 194 patients (January 2008-November 2020), with III-IV locally advanced rectal cancer and subjected to pCRT were included. Three expert radiologists performed DCE-MRI analysis using SIS tool. Degree of absolute agreement among measurements, degree of consistency among measurements, degree of reliability and level of variability were calculated. Patients with a pathological tumour regression grade (TRG) 1 or 2 were classified as major responders (complete responders have TRG 1). Results: Good significant correlation was obtained between SIS measurements (range 0.97-0.99). The degree of absolute agreement ranges from 0.93 to 0.99, the degree of consistency from 0.81 to 0.9 and the reliability from 0.98 to 1.00 (p value
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