The Triglycerides and Glucose Index Is Associated with Mild Cognitive Impairment in Older Adults

It has been reported that insulin resistance is related to cognitive decline. The triglycerides and glucose (TyG) index, is a reliable and inexpensive surrogate test for detecting insulin resistance.The goal of this study was to evaluate the association between the TyG index and the mild cognitive impairment (MCI) in older adults.A total of 135 individuals, men and women aged 60 to 90 years, were enrolled in a case and control study. Individuals with a diagnosis of MCI (n = 65) were allocated into the case group and compared with individuals without MCI (n = 70) in the control group. Alcohol intake, diabetes duration ≥5 years, diagnoses of cerebrovascular disease, brain injury, folic acid deficiency, dementia, moderate or severe CI, major depressive disorders, and thyroid disease were exclusion criteria.Individuals in the case group exhibited higher waist circumference (97.9 ± 13.9The TyG index is independently associated with the presence of MCI in older people.