HLA-G gene 14-bp deletion variant protects Iranian subjects against chronic hepatitis B infection

Summary To investigate whether 14-bp Ins/Del polymorphism in HLA-G gene is associated with the risk of chronic hepatitis B (CHB) infection. This study was performed on a total of 396 individuals including 199 CHB patients and 197 healthy subjects from a south-east Iranian population. We genotyped 14-bp Ins/Del polymorphism in the HLA-G gene using polymerase chain reaction method. The results of our study revealed that the HLA-G 14-bp deletion polymorphism was associated with a reduced risk of CHB at both allele and genotypic levels. The 14-bp Del allele and Ins/Del genotype were more frequent in control group than in CHB patients (37% vs 28% for Del allele with OR = 0.68 and p-value = .015; 73% vs 52% for Ins/Del genotype with OR = 0.43 and p-value = .001) and both were protective factors against CHB. However, no difference was found in the distribution of HLA-G 14-bp genotypes among subjects with varied levels of HBV DNA or hepatic enzymes (p > .05). Our findings, for the first time, suggest that the HLA-G 14-bp Ins/Del polymorphism may be a marker for genetic susceptibility to CHB infection.