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Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects

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  • معلومة اضافية
    • Contributors:
      RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health; Promovendi NTM; Nutrition and Movement Sciences
    • بيانات النشر:
      Springer, 2019.
    • الموضوع:
      2019
    • نبذة مختصرة :
      Backgound Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. Objective To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postprandial vascular function markers. Design In a randomized, double-blind crossover study, 44 apparently healthy overweight (N = 30) and obese (N = 14) men and women with low HDL-C concentrations, consumed daily 500 mg theobromine or placebo for 4 weeks. After 4 weeks, FMD, peripheral arterial tonometry (PAT), augmentation index (AIx), pulse wave velocity (PWV), blood pressure (BP) and retinal microvasculature measurements were performed. These measurements were carried out under fasting conditions and 2.5 h after a high-fat mixed meal challenge. Results 4-week theobromine consumption did not change fasting vascular function markers, except for a decrease in central AIx (cAIx, − 1.7 pp, P = 0.037) and a trend towards smaller venular calibers (− 2 µm, P = 0.074). Consuming a high-fat mixed meal decreased FMD (0.89 pp, P = 0.002), reactive hyperemia index (RHI, − 0.30, P
    • ISSN:
      1436-6215
      1436-6207
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....6de5fb22801c04812a79a50e0b9151a2